Right ventricular distension and left ventricular compliance.

B. H. Lorell, I. Palacios, W. M. Daggett, Marshall L Jacobs, B. N. Fowler, J. B. Newell

Research output: Contribution to journalArticle

Abstract

The constraint of the right ventricle (RV) on the end-diastolic pressure-volume (PV) relationship of the nonischemic and ischemic left ventricle (LV) was studied. The model used was the isovolumic beating LV, with separately perfused ejecting RV with controlled RV distension. The effect of augmented RV distension on the nonischemic LV PV relationship was examined. A change from mild [right ventricular end-diastolic pressure (RVEDP) = 1.5 mm Hg] to severe (RVEDP = 16 mmHg) RV distension resulted in a significant leftward shift of the LV PV relationship. Ischemia was produced for 90 min by reducing flow in the cannulated left main coronary artery and the effect of two levels of stable RV distension on the PV relationship of the ischemic LV was examined. Mild RV distension and moderate (RVEDP = 6 mmHg) RV distension were used. In both groups, there was a progressive leftward shift in the LV PV relationship that was significant by 60 min of ischemia. No change was seen in nonischemic controls. Ventricular relaxation, as described by the time constant of isovolumic relaxation, T, was impaired throughout ischemia but was not sufficiently prolonged to explain the above changes. Thus, the time course of change in the LV PV relationship during ischemia differs from that previously reported after pacing-induced ischemia in humans. Neither the external constraint of the RV nor incomplete relaxation explains this difference.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume240
Issue number1
StatePublished - Jan 1981
Externally publishedYes

Fingerprint

Compliance
Heart Ventricles
Ischemia
Pressure
Blood Pressure
Coronary Vessels

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lorell, B. H., Palacios, I., Daggett, W. M., Jacobs, M. L., Fowler, B. N., & Newell, J. B. (1981). Right ventricular distension and left ventricular compliance. The American journal of physiology, 240(1).

Right ventricular distension and left ventricular compliance. / Lorell, B. H.; Palacios, I.; Daggett, W. M.; Jacobs, Marshall L; Fowler, B. N.; Newell, J. B.

In: The American journal of physiology, Vol. 240, No. 1, 01.1981.

Research output: Contribution to journalArticle

Lorell, BH, Palacios, I, Daggett, WM, Jacobs, ML, Fowler, BN & Newell, JB 1981, 'Right ventricular distension and left ventricular compliance.', The American journal of physiology, vol. 240, no. 1.
Lorell BH, Palacios I, Daggett WM, Jacobs ML, Fowler BN, Newell JB. Right ventricular distension and left ventricular compliance. The American journal of physiology. 1981 Jan;240(1).
Lorell, B. H. ; Palacios, I. ; Daggett, W. M. ; Jacobs, Marshall L ; Fowler, B. N. ; Newell, J. B. / Right ventricular distension and left ventricular compliance. In: The American journal of physiology. 1981 ; Vol. 240, No. 1.
@article{849ee3c1e1374fc49434620fadb9547c,
title = "Right ventricular distension and left ventricular compliance.",
abstract = "The constraint of the right ventricle (RV) on the end-diastolic pressure-volume (PV) relationship of the nonischemic and ischemic left ventricle (LV) was studied. The model used was the isovolumic beating LV, with separately perfused ejecting RV with controlled RV distension. The effect of augmented RV distension on the nonischemic LV PV relationship was examined. A change from mild [right ventricular end-diastolic pressure (RVEDP) = 1.5 mm Hg] to severe (RVEDP = 16 mmHg) RV distension resulted in a significant leftward shift of the LV PV relationship. Ischemia was produced for 90 min by reducing flow in the cannulated left main coronary artery and the effect of two levels of stable RV distension on the PV relationship of the ischemic LV was examined. Mild RV distension and moderate (RVEDP = 6 mmHg) RV distension were used. In both groups, there was a progressive leftward shift in the LV PV relationship that was significant by 60 min of ischemia. No change was seen in nonischemic controls. Ventricular relaxation, as described by the time constant of isovolumic relaxation, T, was impaired throughout ischemia but was not sufficiently prolonged to explain the above changes. Thus, the time course of change in the LV PV relationship during ischemia differs from that previously reported after pacing-induced ischemia in humans. Neither the external constraint of the RV nor incomplete relaxation explains this difference.",
author = "Lorell, {B. H.} and I. Palacios and Daggett, {W. M.} and Jacobs, {Marshall L} and Fowler, {B. N.} and Newell, {J. B.}",
year = "1981",
month = "1",
language = "English (US)",
volume = "240",
journal = "American Journal of Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "1",

}

TY - JOUR

T1 - Right ventricular distension and left ventricular compliance.

AU - Lorell, B. H.

AU - Palacios, I.

AU - Daggett, W. M.

AU - Jacobs, Marshall L

AU - Fowler, B. N.

AU - Newell, J. B.

PY - 1981/1

Y1 - 1981/1

N2 - The constraint of the right ventricle (RV) on the end-diastolic pressure-volume (PV) relationship of the nonischemic and ischemic left ventricle (LV) was studied. The model used was the isovolumic beating LV, with separately perfused ejecting RV with controlled RV distension. The effect of augmented RV distension on the nonischemic LV PV relationship was examined. A change from mild [right ventricular end-diastolic pressure (RVEDP) = 1.5 mm Hg] to severe (RVEDP = 16 mmHg) RV distension resulted in a significant leftward shift of the LV PV relationship. Ischemia was produced for 90 min by reducing flow in the cannulated left main coronary artery and the effect of two levels of stable RV distension on the PV relationship of the ischemic LV was examined. Mild RV distension and moderate (RVEDP = 6 mmHg) RV distension were used. In both groups, there was a progressive leftward shift in the LV PV relationship that was significant by 60 min of ischemia. No change was seen in nonischemic controls. Ventricular relaxation, as described by the time constant of isovolumic relaxation, T, was impaired throughout ischemia but was not sufficiently prolonged to explain the above changes. Thus, the time course of change in the LV PV relationship during ischemia differs from that previously reported after pacing-induced ischemia in humans. Neither the external constraint of the RV nor incomplete relaxation explains this difference.

AB - The constraint of the right ventricle (RV) on the end-diastolic pressure-volume (PV) relationship of the nonischemic and ischemic left ventricle (LV) was studied. The model used was the isovolumic beating LV, with separately perfused ejecting RV with controlled RV distension. The effect of augmented RV distension on the nonischemic LV PV relationship was examined. A change from mild [right ventricular end-diastolic pressure (RVEDP) = 1.5 mm Hg] to severe (RVEDP = 16 mmHg) RV distension resulted in a significant leftward shift of the LV PV relationship. Ischemia was produced for 90 min by reducing flow in the cannulated left main coronary artery and the effect of two levels of stable RV distension on the PV relationship of the ischemic LV was examined. Mild RV distension and moderate (RVEDP = 6 mmHg) RV distension were used. In both groups, there was a progressive leftward shift in the LV PV relationship that was significant by 60 min of ischemia. No change was seen in nonischemic controls. Ventricular relaxation, as described by the time constant of isovolumic relaxation, T, was impaired throughout ischemia but was not sufficiently prolonged to explain the above changes. Thus, the time course of change in the LV PV relationship during ischemia differs from that previously reported after pacing-induced ischemia in humans. Neither the external constraint of the RV nor incomplete relaxation explains this difference.

UR - http://www.scopus.com/inward/record.url?scp=0019493124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019493124&partnerID=8YFLogxK

M3 - Article

VL - 240

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0363-6135

IS - 1

ER -