TY - JOUR
T1 - Right ventricular diastolic relaxation in conscious dog models of pressure overload, volume overload, and ischemia
AU - Pasipoularides, Ares D.
AU - Shu, Ming
AU - Shah, Ashish
AU - Glower, Donald D.
PY - 2002/11/1
Y1 - 2002/11/1
N2 - Objective: Limitations in clinical understanding of right ventricular relaxation can be attributed to the paucity of information from basic studies in animal models of right ventricular disease. This study examined, in the conscious state, right ventricular relaxation dynamics under normal conditions (n = 15) and in subacute (2-5 weeks) canine models of right ventricular pressure overload (n = 6), volume overload (n = 7), and free wall ischemia (n = 7). Methods: Right-heart micromanometric measurements were obtained by using multisensor catheters. A new algorithm was developed to obtain representative ensemble averages of hemodynamic waveform data sets. Right ventricular relaxation was analyzed by using an exponential model with 3 parameters: P0, τ, and Pb. Significant changes versus control values were determined by means of analysis of variance and the Student unpaired t test with Bonferroni's adjustment. Results: In the state of pressure overload, right ventricular pressure decay exhibits an increased P0 (56.2 ± 19.1 vs 13.1 ± 5.1 mm Hg [mean ± SD]) and prolonged τ (57.1 ± 2.8 vs 27.8 ± 3.9 ms); there is also a decreased Pb (-7.9 ± 1.5 vs 0.28 ± 1.8 mm Hg). The only significant change in volume overload is an increased asymptote, Pb (5.3 ± 2.9 mm Hg). In right ventricular ischemia, prolongation of τ (41.4 ± 13.0 ms) and decreased Pb (- 1.95 ± 1.1 mm Hg) attain high significance. Conclusions: Distinctive abnormalities in right ventricular relaxation dynamics accompany pressure overload, volume overload, and ischemia and may contribute to clinical right ventricular dysfunction.
AB - Objective: Limitations in clinical understanding of right ventricular relaxation can be attributed to the paucity of information from basic studies in animal models of right ventricular disease. This study examined, in the conscious state, right ventricular relaxation dynamics under normal conditions (n = 15) and in subacute (2-5 weeks) canine models of right ventricular pressure overload (n = 6), volume overload (n = 7), and free wall ischemia (n = 7). Methods: Right-heart micromanometric measurements were obtained by using multisensor catheters. A new algorithm was developed to obtain representative ensemble averages of hemodynamic waveform data sets. Right ventricular relaxation was analyzed by using an exponential model with 3 parameters: P0, τ, and Pb. Significant changes versus control values were determined by means of analysis of variance and the Student unpaired t test with Bonferroni's adjustment. Results: In the state of pressure overload, right ventricular pressure decay exhibits an increased P0 (56.2 ± 19.1 vs 13.1 ± 5.1 mm Hg [mean ± SD]) and prolonged τ (57.1 ± 2.8 vs 27.8 ± 3.9 ms); there is also a decreased Pb (-7.9 ± 1.5 vs 0.28 ± 1.8 mm Hg). The only significant change in volume overload is an increased asymptote, Pb (5.3 ± 2.9 mm Hg). In right ventricular ischemia, prolongation of τ (41.4 ± 13.0 ms) and decreased Pb (- 1.95 ± 1.1 mm Hg) attain high significance. Conclusions: Distinctive abnormalities in right ventricular relaxation dynamics accompany pressure overload, volume overload, and ischemia and may contribute to clinical right ventricular dysfunction.
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U2 - 10.1067/mtc.2002.126677
DO - 10.1067/mtc.2002.126677
M3 - Article
C2 - 12407380
AN - SCOPUS:0036828731
SN - 0022-5223
VL - 124
SP - 964
EP - 972
JO - Journal of Thoracic and Cardiovascular Surgery
JF - Journal of Thoracic and Cardiovascular Surgery
IS - 5
ER -