Right ventricular diastolic function in canine models of pressure overload, volume overload, and ischemia

Ares Pasipoularides, Ming Shu, Ashish Shah, Scott Silvestry, Donald D. Glower

Research output: Contribution to journalArticle

Abstract

By limiting filling, abnormalities of right ventricular (RV) diastolic function may impair systolic function and affect adaptation to disease. To quantify diastolic RV pressure-volume relations and myocardial compliance (MC), a new sigmoidal model was developed. RV micromanometric and sonomicrometric data in alert dogs at control (n = 16) and under surgically induced subacute (2-5 wk) RV pressure overload (n = 6), volume overload (n = 7), and ischemia (n = 6) were analyzed. The conventional exponential model detected no changes from control in the passive filling pressure-volume (P pf-V) relations. The new sigmoidal model revealed significant quantifiable changes in P pf-V relations. Maximum RV MC (MC max), attained during early filling, is reduced from control in pressure overload (P = 0.0016), whereas filling pressure at maximum MC (P MCmax) is increased (P = 0.0001). End-diastolic RV MC increases significantly in volume overload (P = 0.0131), whereas enddiastolic pressure is unchanged. In ischemia, MC max is decreased (P = 0.0102), with no change in P MCmax. We conclude that the sigmoidal model quantifies important changes in RV diastolic function in alert dog models of pressure overload, volume overload, and ischemia.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume283
Issue number5 52-5
Publication statusPublished - Nov 1 2002
Externally publishedYes

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Keywords

  • Diastole
  • Dynamics
  • Heart failure
  • Myocardial compliance
  • Right ventricle

ASJC Scopus subject areas

  • Physiology

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