TY - JOUR
T1 - Richter's syndrome with two different B‐cell clones
AU - McDonnell, Jan M.
AU - Beschorner, William E.
AU - Staal, Stephen P.
AU - Spivak, Jerry L.
AU - Mann, Risa B.
PY - 1986/11/1
Y1 - 1986/11/1
N2 - The diagnoses of chronic lymphocytic leukemia (CLL) in prolymphocytic transformation, and diffuse large cell lymphoma (DLC), were made simultaneously in a 71‐year‐old man. The DLC showed mu lambda surface immunoglobulin. The CLL in a lymph node and in the peripheral blood showed mu kappa. Immunoglobulin gene DNA analysis confirmed the presence of different rearrangements in the heavy and light chain genes of the CLL and DLC. Other cases reported of Richter's syndrome are discussed, and it is concluded that there may be two types of Richter's syndrome, those arising from transformation of a single clone, and those occurring from expansion of two morphologically and immunologically distinct clones, as, it is believed, is the case in this patient.
AB - The diagnoses of chronic lymphocytic leukemia (CLL) in prolymphocytic transformation, and diffuse large cell lymphoma (DLC), were made simultaneously in a 71‐year‐old man. The DLC showed mu lambda surface immunoglobulin. The CLL in a lymph node and in the peripheral blood showed mu kappa. Immunoglobulin gene DNA analysis confirmed the presence of different rearrangements in the heavy and light chain genes of the CLL and DLC. Other cases reported of Richter's syndrome are discussed, and it is concluded that there may be two types of Richter's syndrome, those arising from transformation of a single clone, and those occurring from expansion of two morphologically and immunologically distinct clones, as, it is believed, is the case in this patient.
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U2 - 10.1002/1097-0142(19861101)58:9<2031::AID-CNCR2820580913>3.0.CO;2-J
DO - 10.1002/1097-0142(19861101)58:9<2031::AID-CNCR2820580913>3.0.CO;2-J
M3 - Article
C2 - 3093055
AN - SCOPUS:0022447453
SN - 0008-543X
VL - 58
SP - 2031
EP - 2037
JO - Cancer
JF - Cancer
IS - 9
ER -