TY - JOUR
T1 - Rice Intake, Arsenic Exposure, and Subclinical Cardiovascular Disease Among US Adults in MESA
AU - Sobel, Marisa H.
AU - Sanchez, Tiffany R.
AU - Jones, Miranda R.
AU - Kaufman, Joel D.
AU - Francesconi, Kevin A.
AU - Blaha, Michael J.
AU - Vaidya, Dhananjay
AU - Shimbo, Daichi
AU - Gossler, Walter
AU - Gamble, Mary V.
AU - Genkinger, Jeanine M.
AU - Navas-Acien, Ana
N1 - Funding Information:
The authors thank the other investigators, the staff, and the participants of MESA (Multi-Ethnic Study of Atherosclerosis) for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org. Author contributions: (1) designed research (Drs Navas-Acien, Kaufman, and Blaha), (2) conducted research (Drs Francesconi and Gossler), (3) analyzed data (M.H. Sobel and Dr Sanchez), (4) wrote article (M.H. Sobel and Drs Sanchez, Jones, Blaha, Vaidya, Shimbo, Gamble, Genkinger, and Navas-Acien), and (5) had primary responsibility for final content (Drs Sanchez, Jones, Blaha, Shimbo, Gamble, Genkinger, and Navas-Acien).
PY - 2020/2/18
Y1 - 2020/2/18
N2 - Background: Arsenic-related cardiovascular effects at exposure levels below the US Environmental Protection Agency's standard of 10 μg/L are unclear. For these populations, food, especially rice, is a major source of exposure. We investigated associations of rice intake, a marker of arsenic exposure, with subclinical cardiovascular disease (CVD) markers in a multiethnic population. Methods and Results: Between 2000 and 2002, MESA (Multi-Ethnic Study of Atherosclerosis) enrolled 6814 adults without clinical CVD. We included 5050 participants with baseline data on rice intake and markers of 3 CVD domains: inflammation (hsCRP [high-sensitivity C-reactive protein], interleukin-6, and fibrinogen), vascular function (aortic distensibility, carotid distensibility, and brachial flow-mediated dilation), and subclinical atherosclerosis at 3 vascular sites (carotid intima-media thickness, coronary artery calcification, and ankle-brachial index). We also evaluated endothelial-related biomarkers previously associated with arsenic. Rice intake was assessed by food frequency questionnaire. Urinary arsenic was measured in 310 participants. A total of 13% of participants consumed ≥1 serving of rice/day. Compared with individuals consuming <1 serving of rice/week, ≥1 serving of rice/day was not associated with subclinical markers after demographic, lifestyle, and CVD risk factor adjustment (eg, geometric mean ratio [95% CI] for hsCRP, 0.98 [0.86–1.11]; aortic distensibility, 0.99 [0.91–1.07]; and carotid intima-media thickness, 0.98 [0.91–1.06]). Associations with urinary arsenic were similar to those for rice intake. Conclusions: Rice intake was not associated with subclinical CVD markers in a multiethnic US population. Research using urinary arsenic is needed to assess potential CVD effects of low-level arsenic exposure. Understanding the role of low-level arsenic as it relates to subclinical CVD may contribute to CVD prevention and control.
AB - Background: Arsenic-related cardiovascular effects at exposure levels below the US Environmental Protection Agency's standard of 10 μg/L are unclear. For these populations, food, especially rice, is a major source of exposure. We investigated associations of rice intake, a marker of arsenic exposure, with subclinical cardiovascular disease (CVD) markers in a multiethnic population. Methods and Results: Between 2000 and 2002, MESA (Multi-Ethnic Study of Atherosclerosis) enrolled 6814 adults without clinical CVD. We included 5050 participants with baseline data on rice intake and markers of 3 CVD domains: inflammation (hsCRP [high-sensitivity C-reactive protein], interleukin-6, and fibrinogen), vascular function (aortic distensibility, carotid distensibility, and brachial flow-mediated dilation), and subclinical atherosclerosis at 3 vascular sites (carotid intima-media thickness, coronary artery calcification, and ankle-brachial index). We also evaluated endothelial-related biomarkers previously associated with arsenic. Rice intake was assessed by food frequency questionnaire. Urinary arsenic was measured in 310 participants. A total of 13% of participants consumed ≥1 serving of rice/day. Compared with individuals consuming <1 serving of rice/week, ≥1 serving of rice/day was not associated with subclinical markers after demographic, lifestyle, and CVD risk factor adjustment (eg, geometric mean ratio [95% CI] for hsCRP, 0.98 [0.86–1.11]; aortic distensibility, 0.99 [0.91–1.07]; and carotid intima-media thickness, 0.98 [0.91–1.06]). Associations with urinary arsenic were similar to those for rice intake. Conclusions: Rice intake was not associated with subclinical CVD markers in a multiethnic US population. Research using urinary arsenic is needed to assess potential CVD effects of low-level arsenic exposure. Understanding the role of low-level arsenic as it relates to subclinical CVD may contribute to CVD prevention and control.
KW - arsenic
KW - cardiovascular disease
KW - inflammation
KW - rice
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U2 - 10.1161/JAHA.119.015658
DO - 10.1161/JAHA.119.015658
M3 - Article
C2 - 32067593
AN - SCOPUS:85079617175
VL - 9
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
SN - 2047-9980
IS - 4
M1 - e015658
ER -