Ribosomes and translation

Rachel Green, Harry F. Noller

Research output: Contribution to journalArticle

Abstract

The ribosome is a large multifunctional complex composed of both RNA and proteins. Biophysical methods are yielding low-resolution structures of the overall architecture of ribosomes, and high-resolution structures of individual proteins and segments of rRNA. Accumulating evidence suggests that the ribosomal RNAs play central roles in the critical ribosomal functions of tRNA selection and binding, translocation, and peptidyl transferase. Biochemical and genetic approaches have identified specific functional interactions involving conserved nucleotides in 16S and 23S rRNA. The results obtained by these quite different approaches have begun to converge and promise to yield an unprecedented view of the mechanism of translation in the coming years.

Original languageEnglish (US)
Pages (from-to)679-716
Number of pages38
JournalAnnual Review of Biochemistry
Volume66
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Ribosomes
Peptidyl Transferases
Ribosomal RNA
Transfer RNA
Molecular Biology
Proteins
Nucleotides
RNA

Keywords

  • mRNA decoding
  • Peptidyl transferase
  • Ribosomes
  • rRNA structure
  • Translation

ASJC Scopus subject areas

  • Biochemistry

Cite this

Ribosomes and translation. / Green, Rachel; Noller, Harry F.

In: Annual Review of Biochemistry, Vol. 66, 1997, p. 679-716.

Research output: Contribution to journalArticle

Green, Rachel ; Noller, Harry F. / Ribosomes and translation. In: Annual Review of Biochemistry. 1997 ; Vol. 66. pp. 679-716.
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