Ribosomes and translation

Rachel Green, Harry F. Noller

Research output: Contribution to journalReview articlepeer-review


The ribosome is a large multifunctional complex composed of both RNA and proteins. Biophysical methods are yielding low-resolution structures of the overall architecture of ribosomes, and high-resolution structures of individual proteins and segments of rRNA. Accumulating evidence suggests that the ribosomal RNAs play central roles in the critical ribosomal functions of tRNA selection and binding, translocation, and peptidyl transferase. Biochemical and genetic approaches have identified specific functional interactions involving conserved nucleotides in 16S and 23S rRNA. The results obtained by these quite different approaches have begun to converge and promise to yield an unprecedented view of the mechanism of translation in the coming years.

Original languageEnglish (US)
Pages (from-to)679-716
Number of pages38
JournalAnnual review of biochemistry
StatePublished - Jul 11 1997
Externally publishedYes


  • Peptidyl transferase
  • Ribosomes
  • Translation
  • mRNA decoding
  • rRNA structure

ASJC Scopus subject areas

  • Biochemistry


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