Ribosome pausing, arrest and rescue in bacteria and eukaryotes

Research output: Contribution to journalReview articlepeer-review

Abstract

Ribosomes translate genetic information into polypeptides in several basic steps: initiation, elongation, termination and recycling. When ribosomes are arrested during elongation or termination, the cell’s capacity for protein synthesis is reduced. There are numerous quality control systems in place to distinguish between paused ribosomes that need some extra input to proceed and terminally stalled ribosomes that need to be rescued. Here, we discuss similarities and differences in the systems for resolution of pauses and rescue of arrested ribosomes in bacteria and eukaryotes, and how ribosome profiling has transformed our ability to decipher these molecular events. This article is part of the themed issue ‘Perspectives on the ribosome’.

Original languageEnglish (US)
Article number20160183
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume372
Issue number1716
DOIs
StatePublished - Mar 19 2017

Keywords

  • Dom34/PELO
  • EFP
  • Hbs1/HBS11
  • Rli1/ABCE1
  • TmRNA
  • eIF5A

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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