Rhob: Team oncogene or team tumor suppressor?

Julia A. Ju, Daniele Gilkes

Research output: Contribution to journalReview article

Abstract

Although Rho GTPases RhoA, RhoB, and RhoC share more than 85% amino acid sequence identity, they play very distinct roles in tumor progression. RhoA and RhoC have been suggested in many studies to contribute positively to tumor development, but the role of RhoB in cancer remains elusive. RhoB contains a unique C-terminal region that undergoes specific post-translational modifications affecting its localization and function. In contrast to RhoA and RhoC, RhoB not only localizes at the plasma membrane, but also on endosomes, multivesicular bodies and has even been identified in the nucleus. These unique features are what contribute to the diversity and potentially opposing functions of RhoB in the tumor microenvironment. Here, we discuss the dualistic role that RhoB plays as both an oncogene and tumor suppressor in the context of cancer development and progression.

Original languageEnglish (US)
Article number67
JournalGenes
Volume9
Issue number2
DOIs
StatePublished - Feb 1 2018

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Oncogenes
Neoplasms
Multivesicular Bodies
rho GTP-Binding Proteins
Tumor Microenvironment
Endosomes
Post Translational Protein Processing
Amino Acid Sequence
Cell Membrane

Keywords

  • Cancer progression
  • Oncogene
  • Oncojanus genes
  • Rho GTPases
  • RhoB
  • Tumor suppressor genes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Rhob : Team oncogene or team tumor suppressor? / Ju, Julia A.; Gilkes, Daniele.

In: Genes, Vol. 9, No. 2, 67, 01.02.2018.

Research output: Contribution to journalReview article

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title = "Rhob: Team oncogene or team tumor suppressor?",
abstract = "Although Rho GTPases RhoA, RhoB, and RhoC share more than 85{\%} amino acid sequence identity, they play very distinct roles in tumor progression. RhoA and RhoC have been suggested in many studies to contribute positively to tumor development, but the role of RhoB in cancer remains elusive. RhoB contains a unique C-terminal region that undergoes specific post-translational modifications affecting its localization and function. In contrast to RhoA and RhoC, RhoB not only localizes at the plasma membrane, but also on endosomes, multivesicular bodies and has even been identified in the nucleus. These unique features are what contribute to the diversity and potentially opposing functions of RhoB in the tumor microenvironment. Here, we discuss the dualistic role that RhoB plays as both an oncogene and tumor suppressor in the context of cancer development and progression.",
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AB - Although Rho GTPases RhoA, RhoB, and RhoC share more than 85% amino acid sequence identity, they play very distinct roles in tumor progression. RhoA and RhoC have been suggested in many studies to contribute positively to tumor development, but the role of RhoB in cancer remains elusive. RhoB contains a unique C-terminal region that undergoes specific post-translational modifications affecting its localization and function. In contrast to RhoA and RhoC, RhoB not only localizes at the plasma membrane, but also on endosomes, multivesicular bodies and has even been identified in the nucleus. These unique features are what contribute to the diversity and potentially opposing functions of RhoB in the tumor microenvironment. Here, we discuss the dualistic role that RhoB plays as both an oncogene and tumor suppressor in the context of cancer development and progression.

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