Rheumatoid arthritis in a Chippewa band. II. Field study with clinical serologic and HLA-D correlations

J. Harvey, M. Lotze, F. C. Arnett, W. B. Bias, L. M. Billingsley, E. Harvey, S. H. Hsu, J. D. Sutton, T. M. Zizic, M. B. Stevens

Research output: Contribution to journalArticlepeer-review

Abstract

We present an in-depth study of rheumatoid arthritis (RA) in a Chippewa band. Of the 227 band members, 168 (74%) were evaluated. The unusually high prevalence of RA was confirmed in 7.1% of those studied or, minimally, 5.3% with a 100% completion rate without additional cases found. Seropositivity in those with clinically definite RA was 92% relative to rheumatoid factor and 75% for ANA. Despite the high prevalence (68%) of HLA-DR4 in this closed population, there was a significant correlation of DR4 with RA (100%). The implications of these observations in this population isolate are discussed.

Original languageEnglish (US)
Pages (from-to)28-32
Number of pages5
JournalJournal of Rheumatology
Volume10
Issue number1
StatePublished - Sep 23 1983
Externally publishedYes

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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