Rheumatoid arthritis in a Chippewa band. II. Field study with clinical serologic and HLA-D correlations

J. Harvey; M. Lotze; F. C. Arnett; W. B. Bias; L. M. Billingsley; E. Harvey; S. H. Hsu; J. D. Sutton; T. M. Zizic; M. B. Stevens

Rheumatoid arthritis in a Chippewa band. II. Field study with clinical serologic and HLA-D correlations

J. Harvey, M. Lotze, F. C. Arnett, W. B. Bias, L. M. Billingsley, E. Harvey, S. H. Hsu, J. D. Sutton, T. M. Zizic, M. B. Stevens

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

We present an in-depth study of rheumatoid arthritis (RA) in a Chippewa band. Of the 227 band members, 168 (74%) were evaluated. The unusually high prevalence of RA was confirmed in 7.1% of those studied or, minimally, 5.3% with a 100% completion rate without additional cases found. Seropositivity in those with clinically definite RA was 92% relative to rheumatoid factor and 75% for ANA. Despite the high prevalence (68%) of HLA-DR4 in this closed population, there was a significant correlation of DR4 with RA (100%). The implications of these observations in this population isolate are discussed.

Original language	English (US)
Pages (from-to)	28-32
Number of pages	5
Journal	Journal of Rheumatology
Volume	10
Issue number	1
State	Published - Sep 23 1983
Externally published	Yes

ASJC Scopus subject areas

Rheumatology
Immunology and Allergy
Immunology

Cite this

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title = "Rheumatoid arthritis in a Chippewa band. II. Field study with clinical serologic and HLA-D correlations",

abstract = "We present an in-depth study of rheumatoid arthritis (RA) in a Chippewa band. Of the 227 band members, 168 (74%) were evaluated. The unusually high prevalence of RA was confirmed in 7.1% of those studied or, minimally, 5.3% with a 100% completion rate without additional cases found. Seropositivity in those with clinically definite RA was 92% relative to rheumatoid factor and 75% for ANA. Despite the high prevalence (68%) of HLA-DR4 in this closed population, there was a significant correlation of DR4 with RA (100%). The implications of these observations in this population isolate are discussed.",

author = "J. Harvey and M. Lotze and Arnett, {F. C.} and Bias, {W. B.} and Billingsley, {L. M.} and E. Harvey and Hsu, {S. H.} and Sutton, {J. D.} and Zizic, {T. M.} and Stevens, {M. B.}",

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AU - Harvey, J.

AU - Lotze, M.

AU - Arnett, F. C.

AU - Bias, W. B.

AU - Billingsley, L. M.

AU - Harvey, E.

AU - Hsu, S. H.

AU - Sutton, J. D.

AU - Zizic, T. M.

AU - Stevens, M. B.

PY - 1983/9/23

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N2 - We present an in-depth study of rheumatoid arthritis (RA) in a Chippewa band. Of the 227 band members, 168 (74%) were evaluated. The unusually high prevalence of RA was confirmed in 7.1% of those studied or, minimally, 5.3% with a 100% completion rate without additional cases found. Seropositivity in those with clinically definite RA was 92% relative to rheumatoid factor and 75% for ANA. Despite the high prevalence (68%) of HLA-DR4 in this closed population, there was a significant correlation of DR4 with RA (100%). The implications of these observations in this population isolate are discussed.

AB - We present an in-depth study of rheumatoid arthritis (RA) in a Chippewa band. Of the 227 band members, 168 (74%) were evaluated. The unusually high prevalence of RA was confirmed in 7.1% of those studied or, minimally, 5.3% with a 100% completion rate without additional cases found. Seropositivity in those with clinically definite RA was 92% relative to rheumatoid factor and 75% for ANA. Despite the high prevalence (68%) of HLA-DR4 in this closed population, there was a significant correlation of DR4 with RA (100%). The implications of these observations in this population isolate are discussed.

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Rheumatoid arthritis in a Chippewa band. II. Field study with clinical serologic and HLA-D correlations

Abstract

ASJC Scopus subject areas

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