Rheumatoid arthritis-A sequel to HBsAg hepatitis

E. Morris, Mary Betty Stevens

Research output: Contribution to journalArticle

Abstract

Reported here is the first case of classic rheumatoid arthritis emerging in the setting of hepatitis B surface antigen (HBsAg)-positive viral hepatitis. Polyfocal arthritis and myalgia, lymphadenopathy and constitutional symptoms were the presenting manifestations of anicteric hepatitis in this 23 year old man. Smooth muscle antibodies, HBsAg and "rheumatoid" factor were demonstrated initially. The hepatocellular disease, biopsy-proved, resolved completely and without recurrence; clinically and serologlcally. Latex test positivity persisted, increasing in titer, and polyarthritis progressed to fulfill criteria for classic rheumatoid arthritis, with erosions on roentgenogram and characteristic synovial disease. After 60 months of follow-up, the rheumatold synovitis has continued to progress despite appropriate therapy. The arthritis of viral hepatitis and the significance of rheumatoid factor in association with hepatocellular disease are discussed.

Original languageEnglish (US)
Pages (from-to)859-862
Number of pages4
JournalThe American Journal of Medicine
Volume64
Issue number5
DOIs
StatePublished - Jan 1 1978
Externally publishedYes

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Hepatitis B Surface Antigens
Hepatitis
Rheumatoid Arthritis
Rheumatoid Factor
Arthritis
Infectious Arthritis
Synovitis
Myalgia
Latex
Smooth Muscle
Biopsy
Recurrence
Antibodies
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rheumatoid arthritis-A sequel to HBsAg hepatitis. / Morris, E.; Stevens, Mary Betty.

In: The American Journal of Medicine, Vol. 64, No. 5, 01.01.1978, p. 859-862.

Research output: Contribution to journalArticle

Morris, E. ; Stevens, Mary Betty. / Rheumatoid arthritis-A sequel to HBsAg hepatitis. In: The American Journal of Medicine. 1978 ; Vol. 64, No. 5. pp. 859-862.
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