Rheumatic manifestations among HIV positive adults attending the Infectious Disease Clinic at Mulago hospital

Mark Kaddu-Mukasa, E. Ssekasanvu, E. Ddumba, David L Thomas, E. T. Katabira

Research output: Contribution to journalArticle

Abstract

Background: Rheumatic manifestations in HIV are common and sometimes the initial presentation of the disease. HIV is now a common infection at the Infectious Disease Clinic, Mulago. The spectrum of joint diseases seen depend on a number of factors such as, the CD4 count, HLA status and current therapy. Objective: This study included HIV patients from a heterogeneous population and was designed to determine the prevalence and clinical pattern of rheumatic manifestations among these HIV patients. Methods: Four hundred eighty seven patients were screened and 300 HIV positive patients were consecutively recruited into the study, evaluated for rheumatic manifestations and their clinical and laboratory findings documented. Results: The prevalence of rheumatic manifestations was 27% (81 of 300). Arthralgias in 19.3% of the study population were commonest finding followed by HIV associated arthritis at 4.3%. The lower limbs were the most commonly affected with the knees (28.8%) and ankles (26.9%) contributing the highest. All patients had a negative anti-nuclear antibody test, with only two having a positive rheumatoid factor test. An association of antituberculosis drugs with joint disease was further highlighted in this study (OR 3.79 95% CI, 1.44 - 9.93). Septic arthritis due to Staphylococcus aureus was rarely observed except when the patients' level of CD4 + T cells dropped below 200 cells mm3. The mean CD4+ count was 171 cells mm3. Conclusion: Rheumatic manifestations should be considered among HIV positive adults. Arthralgias are common especially in patients using pyrazinamide.

Original languageEnglish (US)
Pages (from-to)24-29
Number of pages6
JournalAfrican Health Sciences
Volume11
Issue number1
StatePublished - 2011

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Communicable Diseases
HIV
Joint Diseases
Arthralgia
CD4 Lymphocyte Count
Pyrazinamide
Infectious Arthritis
Rheumatoid Factor
Ankle
Population
Arthritis
Staphylococcus aureus
Anti-Idiotypic Antibodies
Lower Extremity
Knee
T-Lymphocytes
Infection
Pharmaceutical Preparations

Keywords

  • Hiv and arthritis
  • Rheumatic manifestations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rheumatic manifestations among HIV positive adults attending the Infectious Disease Clinic at Mulago hospital. / Kaddu-Mukasa, Mark; Ssekasanvu, E.; Ddumba, E.; Thomas, David L; Katabira, E. T.

In: African Health Sciences, Vol. 11, No. 1, 2011, p. 24-29.

Research output: Contribution to journalArticle

Kaddu-Mukasa, Mark ; Ssekasanvu, E. ; Ddumba, E. ; Thomas, David L ; Katabira, E. T. / Rheumatic manifestations among HIV positive adults attending the Infectious Disease Clinic at Mulago hospital. In: African Health Sciences. 2011 ; Vol. 11, No. 1. pp. 24-29.
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