Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation

Wanchun Yang, Dejiang Pang, Mina Chen, Chongyangzi Du, Lanlan Jia, Luoling Wang, Yunling He, Wanxiang Jiang, Liping Luo, Zongyan Yu, Mengqian Mao, Qiuyun Yuan, Ping Tang, Xiaoqiang Xia, Yiyuan Cui, Bo Jing, Alexander Platero, Yanhui Liu, Yuquan Wei, Paul F. WorleyBo Xiao

Research output: Contribution to journalArticlepeer-review

Abstract

Neuronal activity is coordinated with neuroenergetics. Yang et al. demonstrate that dynamic translocation of Rheb to mitochondrial matrix activates pyruvate dehydrogenase (PDH) independent of mTORC1 and mediates neuronal-activity-regulated mitochondrial metabolism. Their findings suggest a mechanism by which Rheb integrates PDH-dependent energy production and mTORC1-dependent energy consumption.

Original languageEnglish (US)
Pages (from-to)811-825.e6
JournalDevelopmental Cell
Volume56
Issue number6
DOIs
StatePublished - Mar 22 2021

Keywords

  • Rheb
  • mTORC1
  • mitochondria
  • neuroenergetics
  • neuronal activity
  • pyruvate dehydrogenase

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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