@article{f9cab631ea204763a680d55aece2ca8d,
title = "Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation",
abstract = "Neuronal activity is coordinated with neuroenergetics. Yang et al. demonstrate that dynamic translocation of Rheb to mitochondrial matrix activates pyruvate dehydrogenase (PDH) independent of mTORC1 and mediates neuronal-activity-regulated mitochondrial metabolism. Their findings suggest a mechanism by which Rheb integrates PDH-dependent energy production and mTORC1-dependent energy consumption.",
keywords = "Rheb, mTORC1, mitochondria, neuroenergetics, neuronal activity, pyruvate dehydrogenase",
author = "Wanchun Yang and Dejiang Pang and Mina Chen and Chongyangzi Du and Lanlan Jia and Luoling Wang and Yunling He and Wanxiang Jiang and Liping Luo and Zongyan Yu and Mengqian Mao and Qiuyun Yuan and Ping Tang and Xiaoqiang Xia and Yiyuan Cui and Bo Jing and Alexander Platero and Yanhui Liu and Yuquan Wei and Worley, {Paul F.} and Bo Xiao",
note = "Funding Information: We thank the Transgenic Facility of Johns Hopkins University School of Medicine for the assistance with the generation of Rosa26 Rheb (wildtype) mouse, Dr. Chenghui Li of the Analytical & Testing Center of Sichuan University for the help with laser scanning confocal imaging, and Ms. Hui Zheng for the artistic work. This work was supported by grants from the National Natural Science Foundation of China ( 31501155 to W.Y., 31530042 , 31371484 to B.X., and 81571195 to M.C.), Shenzhen-Hong Kong Institute of Brain Science- Shenzhen Fundamental Research Institutions ( 2021SHIBS0002 ), and Shenzhen Innovation Committee of Science and Technology Grants. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
month = mar,
day = "22",
doi = "10.1016/j.devcel.2021.02.022",
language = "English (US)",
volume = "56",
pages = "811--825.e6",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "6",
}