Rhabdomyosarcoma complicating multiple neurofibromatosis

E. A. McKeen, Joann N Bodurtha, A. T. Meadows, E. C. Douglass, J. J. Mulvihill

Research output: Contribution to journalArticle


Malignancy develops commonly in patients with multiple neurofibromatosis (von Recklinghausen disease), usually as transformation of a neurofibroma or other tissue of neural crest origin. In addition, neurofibromatosis occurs to excess in patients with leukemia and with Wilms tumor. This paper describes the association of neurofibromatosis and rhabdomyosarcoma, a third malignancy not clearly derived from the neural crest. Five patients with neurofibromatosis are reported among 84 patients with rhabdomyosarcoma from two consecutive series: 4/57 from Children's Hospital of Philadelphia, 1964-1977, and 1/27 from the Pediatric Oncology Branch, National Cancer Institute, 1974-1977. Also 9 examples from the literature are reviewed.

Original languageEnglish (US)
Pages (from-to)992-993
Number of pages2
JournalJournal of Pediatrics
Issue number6
Publication statusPublished - 1978
Externally publishedYes


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

McKeen, E. A., Bodurtha, J. N., Meadows, A. T., Douglass, E. C., & Mulvihill, J. J. (1978). Rhabdomyosarcoma complicating multiple neurofibromatosis. Journal of Pediatrics, 93(6), 992-993. https://doi.org/10.1016/S0022-3476(78)81230-X