Rhabdomyolysis in patients with acute lymphoblastic leukemia

M. Morales-Polanco, F. J. Jimenez-Balderas, L. Butron, Laura Gutierrez, E. Paredes-Gonzalez

Research output: Contribution to journalArticle

Abstract

The objective of this paper is to report 5 cases of rhabdomyolysis (RML) in patients with acute leukemia (AL). This occurred consecutively after the administration of chemotherapy, during the ensuing period of myelosuppression. Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias. Serum creatine kinase (CK), liver function tests and a light microscopy muscle biopsy were performed on all of them. Ten -17 days after receiving chemotherapy, five patients (4 males and 1 female) with acute lymphoblastic leukemia developed incapacitating myalgias in neck, thighs and arms. CK and/or alanine aminotransferase and aspartate aminotransferase were increased 5-24 times above the normal range in four of these patients, and the muscle biopsy showed focal RML in all five. Myalgias were self-limited and lasted 4-10 days. In addition to the chemotherapy, other factors known to be capable of producing RML, such as sepsis, other medications, and dehydration were found. In conclusion, myalgias were due to focal RML produced probably by a combination of factors, particularly the chemotherapy along with dehydration due to gastrointestinal complications, infection, and the use of diverse antibiotics. The endemic nature of the finding in such a short period of time is outstanding.

Original languageEnglish (US)
Pages (from-to)377-381
Number of pages5
JournalArchives of Medical Research
Volume28
Issue number3
StatePublished - 1997
Externally publishedYes

Fingerprint

Rhabdomyolysis
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Myalgia
Drug Therapy
Creatine Kinase
Dehydration
Leukemia
Biopsy
Muscles
Liver Function Tests
Cytarabine
Aspartate Aminotransferases
Thigh
Alanine Transaminase
Gastrointestinal Tract
Microscopy
Sepsis
Reference Values
Arm
Fever

Keywords

  • Acute lymphoblastic leukemia
  • Myelosuppression
  • Rhabdomyolysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Morales-Polanco, M., Jimenez-Balderas, F. J., Butron, L., Gutierrez, L., & Paredes-Gonzalez, E. (1997). Rhabdomyolysis in patients with acute lymphoblastic leukemia. Archives of Medical Research, 28(3), 377-381.

Rhabdomyolysis in patients with acute lymphoblastic leukemia. / Morales-Polanco, M.; Jimenez-Balderas, F. J.; Butron, L.; Gutierrez, Laura; Paredes-Gonzalez, E.

In: Archives of Medical Research, Vol. 28, No. 3, 1997, p. 377-381.

Research output: Contribution to journalArticle

Morales-Polanco, M, Jimenez-Balderas, FJ, Butron, L, Gutierrez, L & Paredes-Gonzalez, E 1997, 'Rhabdomyolysis in patients with acute lymphoblastic leukemia', Archives of Medical Research, vol. 28, no. 3, pp. 377-381.
Morales-Polanco M, Jimenez-Balderas FJ, Butron L, Gutierrez L, Paredes-Gonzalez E. Rhabdomyolysis in patients with acute lymphoblastic leukemia. Archives of Medical Research. 1997;28(3):377-381.
Morales-Polanco, M. ; Jimenez-Balderas, F. J. ; Butron, L. ; Gutierrez, Laura ; Paredes-Gonzalez, E. / Rhabdomyolysis in patients with acute lymphoblastic leukemia. In: Archives of Medical Research. 1997 ; Vol. 28, No. 3. pp. 377-381.
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