TY - JOUR
T1 - Rhabdomyolysis and secondary renal failure in critically ill surgical patients.
AU - Sharp, Lindsey S.
AU - Rozycki, Grace S.
AU - Feliciano, David V.
PY - 2004/12
Y1 - 2004/12
N2 - BACKGROUND: Rhabdomyolysis accounts for up to 28% of the causes of posttraumatic acute renal failure requiring dialysis. Clinically significant rhabdomyolysis is poorly characterized biochemically and difficult to diagnose. METHODS: A retrospective review of all surgical, trauma, burn, and pediatric surgical patients admitted to Grady Memorial Hospital in Atlanta, GA, from January 1995, through April 2002 was performed. Patients were screened for serum creatinine, base deficit, serum creatine kinase (CK) > or =1,000, presence of myoglobinuria, or if they had a clinical diagnosis of rhabdomyolysis by an attending surgeon. RESULTS: The sequential addition of admission laboratory values for serum creatinine > or =1.5 mg/dL (positive predictive value [PPV] = 33%), base deficit < or = -4 (PPV = 52%), serum CK level > or =5,000 U/L (PPV = 80%), and myoglobinuria increases the ability to predict which patients will develop dialysis-requiring acute renal failure after an episode of rhabdomyolysis. Patients with maximum CK > or =5,000 are also at increased risk for persistent renal insufficiency (Cr > or =2.0 mg/dL). CONCLUSIONS: An algorithm for testing at-risk surgical patients was developed and may aid in the early diagnosis of clinically significant rhabdomyolysis.
AB - BACKGROUND: Rhabdomyolysis accounts for up to 28% of the causes of posttraumatic acute renal failure requiring dialysis. Clinically significant rhabdomyolysis is poorly characterized biochemically and difficult to diagnose. METHODS: A retrospective review of all surgical, trauma, burn, and pediatric surgical patients admitted to Grady Memorial Hospital in Atlanta, GA, from January 1995, through April 2002 was performed. Patients were screened for serum creatinine, base deficit, serum creatine kinase (CK) > or =1,000, presence of myoglobinuria, or if they had a clinical diagnosis of rhabdomyolysis by an attending surgeon. RESULTS: The sequential addition of admission laboratory values for serum creatinine > or =1.5 mg/dL (positive predictive value [PPV] = 33%), base deficit < or = -4 (PPV = 52%), serum CK level > or =5,000 U/L (PPV = 80%), and myoglobinuria increases the ability to predict which patients will develop dialysis-requiring acute renal failure after an episode of rhabdomyolysis. Patients with maximum CK > or =5,000 are also at increased risk for persistent renal insufficiency (Cr > or =2.0 mg/dL). CONCLUSIONS: An algorithm for testing at-risk surgical patients was developed and may aid in the early diagnosis of clinically significant rhabdomyolysis.
UR - http://www.scopus.com/inward/record.url?scp=16644398022&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=16644398022&partnerID=8YFLogxK
U2 - 10.1016/j.amjsurg.2004.08.050
DO - 10.1016/j.amjsurg.2004.08.050
M3 - Article
C2 - 15619503
AN - SCOPUS:16644398022
SN - 0002-9610
VL - 188
SP - 801
EP - 806
JO - American journal of surgery
JF - American journal of surgery
IS - 6
ER -