TY - JOUR
T1 - Rhabdomyoblastic Differentiation in Head and Neck Malignancies Other Than Rhabdomyosarcoma
AU - Bishop, Justin A.
AU - Thompson, Lester D R
AU - Cardesa, Antonio
AU - Barnes, Leon
AU - Lewis, James S.
AU - Triantafyllou, Asterios
AU - Hellquist, Henrik
AU - Stenman, Goran
AU - Hunt, Jennifer L.
AU - Williams, Michelle D.
AU - Slootweg, Pieter J.
AU - Devaney, Kenneth O.
AU - Gnepp, Douglas R.
AU - Wenig, Bruce M.
AU - Rinaldo, Alessandra
AU - Ferlito, Alfio
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Rhabdomyosarcoma is a relatively common soft tissue sarcoma that frequently affects children and adolescents and may involve the head and neck. Rhabdomyosarcoma is defined by skeletal muscle differentiation which can be suggested by routine histology and confirmed by immunohistochemistry for the skeletal muscle-specific markers myogenin or myoD1. At the same time, it must be remembered that when it comes to head and neck malignancies, skeletal muscle differentiation is not limited to rhabdomyosarcoma. A lack of awareness of this phenomenon could lead to misdiagnosis and, subsequently, inappropriate therapeutic interventions. This review focuses on malignant neoplasms of the head and neck other than rhabdomyosarcoma that may exhibit rhabdomyoblastic differentiation, with an emphasis on strategies to resolve the diagnostic dilemmas these tumors may present. Axiomatically, no primary central nervous system tumors will be discussed.
AB - Rhabdomyosarcoma is a relatively common soft tissue sarcoma that frequently affects children and adolescents and may involve the head and neck. Rhabdomyosarcoma is defined by skeletal muscle differentiation which can be suggested by routine histology and confirmed by immunohistochemistry for the skeletal muscle-specific markers myogenin or myoD1. At the same time, it must be remembered that when it comes to head and neck malignancies, skeletal muscle differentiation is not limited to rhabdomyosarcoma. A lack of awareness of this phenomenon could lead to misdiagnosis and, subsequently, inappropriate therapeutic interventions. This review focuses on malignant neoplasms of the head and neck other than rhabdomyosarcoma that may exhibit rhabdomyoblastic differentiation, with an emphasis on strategies to resolve the diagnostic dilemmas these tumors may present. Axiomatically, no primary central nervous system tumors will be discussed.
KW - Head and neck malignancies
KW - MyoD1
KW - Myogenin
KW - Rhabdomyoblastic differentiation
KW - Rhabdomyosarcoma
KW - Skeletal muscle differentiation
KW - Soft tissue sarcomas
UR - http://www.scopus.com/inward/record.url?scp=84947615447&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84947615447&partnerID=8YFLogxK
U2 - 10.1007/s12105-015-0624-2
DO - 10.1007/s12105-015-0624-2
M3 - Article
C2 - 25757816
AN - SCOPUS:84947615447
SN - 1936-055X
VL - 9
SP - 507
EP - 518
JO - Head and Neck Pathology
JF - Head and Neck Pathology
IS - 4
ER -