Rhabdoid Meningioma: Cytopathologic Findings in Cerebrospinal Fluid

Anil V. Parwani, Irina Mikolaenko, Charles G. Eberhart, Peter C. Burger, Dorothy L. Rosenthal, Syed Z. Ali

Research output: Contribution to journalArticle

Abstract

Rhabdoid meningioma is a recently described, rare, WHO Grade III intracranial tumor with an aggressive growth pattern and increased risk of recurrence. We describe the cytopathologic findings on cerebrospinal fluid of one such case in a 26-yr-old female who underwent resection of a left temporo-parietal mass. Cerebrospinal fluid contained abundant malignant cells with a prominent "rhabdoid" phenotype, i.e., large cells, eccentric nuclei, single prominent nucleoli, and dense eosinophilic cytoplasm. Although rhabdoid meningioma has a characteristic cytomorphology, the differential diagnosis of this tumor would involve metastatic adenocarcinoma, metastatic malignant melanoma, and other tumors with "rhabdoid" features (such as an atypical teratoid/rhabdoid tumor).

Original languageEnglish (US)
Pages (from-to)297-299
Number of pages3
JournalDiagnostic cytopathology
Volume29
Issue number5
DOIs
StatePublished - Nov 1 2003

Keywords

  • Cerebrospinal fluid
  • Cytopathology
  • Differential diagnosis
  • Rhabdoid meningioma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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