TY - JOUR
T1 - Reward-dependent plasticity in the primary auditory cortex of adult monkeys trained to discriminate temporally modulated signals
AU - Beitel, Ralph E.
AU - Schreiner, Christoph E.
AU - Cheung, Steven W.
AU - Wang, Xiaoqin
AU - Merzenich, Michael M.
PY - 2003/9/16
Y1 - 2003/9/16
N2 - Adult owl monkeys were trained to detect an increase in the envelope frequency of a sinusoidally modulated 1-kHz tone. Detection was positively correlated with the magnitude of the change in the envelope frequency. Surprisingly, neuronal responses recorded in the primary auditory cortex of trained monkeys were globally suppressed by the modulated tone. However, the contrast in neuronal responsiveness to small increases versus large increases in envelope frequencies was actually enhanced in the trained animals. The results suggest behaviorally contingent inhibitory and excitatory processes that are modulated by the probability that a particular signal predicts a reward.
AB - Adult owl monkeys were trained to detect an increase in the envelope frequency of a sinusoidally modulated 1-kHz tone. Detection was positively correlated with the magnitude of the change in the envelope frequency. Surprisingly, neuronal responses recorded in the primary auditory cortex of trained monkeys were globally suppressed by the modulated tone. However, the contrast in neuronal responsiveness to small increases versus large increases in envelope frequencies was actually enhanced in the trained animals. The results suggest behaviorally contingent inhibitory and excitatory processes that are modulated by the probability that a particular signal predicts a reward.
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U2 - 10.1073/pnas.1334187100
DO - 10.1073/pnas.1334187100
M3 - Article
C2 - 12941865
AN - SCOPUS:0141813796
VL - 100
SP - 11070
EP - 11075
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 19
ER -