Revisiting and refining roles of neural guidance cues in circuit assembly

Joelle M. Dorskind, Alex L. Kolodkin

Research output: Contribution to journalReview article

Abstract

Neural guidance mechanisms ensure the precise targeting and synaptogenesis events essential for normal circuit function. Neuronal growth cones encounter numerous attractive and repulsive cues as they navigate toward their intermediate and final targets; temporal and spatial regulation of these responses are critical for circuit assembly. Recent work highlights the complexity of these events throughout neural development and the multifaceted functions of a wide range of guidance cues. Here, we discuss recent studies that leverage advances in genetics, single cell tracing, transcriptomics and proteomics to further our understanding of the molecular mechanisms underlying neural guidance and overall circuit organization.

Original languageEnglish (US)
Pages (from-to)10-21
Number of pages12
JournalCurrent Opinion in Neurobiology
Volume66
DOIs
StatePublished - Feb 2021

ASJC Scopus subject areas

  • Neuroscience(all)

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