Revising the upper limit of normal for levels of serum alanine aminotransferase in a middle eastern population with normal liver histology

Waleed Al-Hamoudi, Safiyya Ali, Bassem Hegab, Hussien Elsiesy, Almoutaz Hashim, Mohammed Al-Sofayan, Hatem Khalaf, Hamad Al-Bahili, Nasser Al-Masri, Mohammed Al-Sebayel, Dieter Broering, Ayman Abdo, Saleh Ali Alqahtani, Faisal Abaalkhail

Research output: Contribution to journalArticle

Abstract

Background: Recently, the upper limits of normal (ULN) for alanine-aminotransferase (ALT) has been recommended to be lowered to ≤30 U/l in men and ≤19 U/l in women. Aim: To evaluate the ALT concentrations in a healthy Middle Eastern population with biopsy-proven normal liver tissue. Methods: ALT values were calculated from 175 consecutive Saudi potential living liver donors who underwent a liver biopsy as part of a stepwise pretransplant workup. Results: The mean age of the 110 potential donors with normal liver histology was 27 ± 6.2 years for men and 38.6 ± 7.1 years for women. The mean body mass index (BMI) levels were 23.0 ± 3.5 kg/m 2 for men and 24.7 ± 3.25 kg/m2 for women, and the ALT levels were higher in male patients (22.6 ± 9 vs. 16.4 U/l ± 8, p value = 0.003). Multivariate linear regression showed that BMI and sex were independent variables that were positively associated with the levels of ALT (p <0.0001). Moreover, when we analyzed donors according to the Prati criteria, 63 (36.0 %) of the individuals were classified into this subgroup. The mean ALT concentration was 12.9 U/l ± 4.5 in women and 19.7 U/l ± 6.9 in men, and these values were significantly lower than those obtained from subjects who did not fit the Prati criteria (19.4 U/l ± 1.8, p = 0.04 for women and 29.0 U/l ± 12.1, p =

Original languageEnglish (US)
Pages (from-to)2369-2375
Number of pages7
JournalDigestive Diseases and Sciences
Volume58
Issue number8
DOIs
StatePublished - Aug 2013
Externally publishedYes

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Alanine Transaminase
Histology
Liver
Serum
Population
Body Mass Index
Tissue Donors
Biopsy
Living Donors
Linear Models

Keywords

  • Alanine aminotransferase
  • Liver biopsy
  • Steatosis
  • Upper limit of normal

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

Revising the upper limit of normal for levels of serum alanine aminotransferase in a middle eastern population with normal liver histology. / Al-Hamoudi, Waleed; Ali, Safiyya; Hegab, Bassem; Elsiesy, Hussien; Hashim, Almoutaz; Al-Sofayan, Mohammed; Khalaf, Hatem; Al-Bahili, Hamad; Al-Masri, Nasser; Al-Sebayel, Mohammed; Broering, Dieter; Abdo, Ayman; Alqahtani, Saleh Ali; Abaalkhail, Faisal.

In: Digestive Diseases and Sciences, Vol. 58, No. 8, 08.2013, p. 2369-2375.

Research output: Contribution to journalArticle

Al-Hamoudi, W, Ali, S, Hegab, B, Elsiesy, H, Hashim, A, Al-Sofayan, M, Khalaf, H, Al-Bahili, H, Al-Masri, N, Al-Sebayel, M, Broering, D, Abdo, A, Alqahtani, SA & Abaalkhail, F 2013, 'Revising the upper limit of normal for levels of serum alanine aminotransferase in a middle eastern population with normal liver histology', Digestive Diseases and Sciences, vol. 58, no. 8, pp. 2369-2375. https://doi.org/10.1007/s10620-013-2659-0
Al-Hamoudi, Waleed ; Ali, Safiyya ; Hegab, Bassem ; Elsiesy, Hussien ; Hashim, Almoutaz ; Al-Sofayan, Mohammed ; Khalaf, Hatem ; Al-Bahili, Hamad ; Al-Masri, Nasser ; Al-Sebayel, Mohammed ; Broering, Dieter ; Abdo, Ayman ; Alqahtani, Saleh Ali ; Abaalkhail, Faisal. / Revising the upper limit of normal for levels of serum alanine aminotransferase in a middle eastern population with normal liver histology. In: Digestive Diseases and Sciences. 2013 ; Vol. 58, No. 8. pp. 2369-2375.
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abstract = "Background: Recently, the upper limits of normal (ULN) for alanine-aminotransferase (ALT) has been recommended to be lowered to ≤30 U/l in men and ≤19 U/l in women. Aim: To evaluate the ALT concentrations in a healthy Middle Eastern population with biopsy-proven normal liver tissue. Methods: ALT values were calculated from 175 consecutive Saudi potential living liver donors who underwent a liver biopsy as part of a stepwise pretransplant workup. Results: The mean age of the 110 potential donors with normal liver histology was 27 ± 6.2 years for men and 38.6 ± 7.1 years for women. The mean body mass index (BMI) levels were 23.0 ± 3.5 kg/m 2 for men and 24.7 ± 3.25 kg/m2 for women, and the ALT levels were higher in male patients (22.6 ± 9 vs. 16.4 U/l ± 8, p value = 0.003). Multivariate linear regression showed that BMI and sex were independent variables that were positively associated with the levels of ALT (p <0.0001). Moreover, when we analyzed donors according to the Prati criteria, 63 (36.0 {\%}) of the individuals were classified into this subgroup. The mean ALT concentration was 12.9 U/l ± 4.5 in women and 19.7 U/l ± 6.9 in men, and these values were significantly lower than those obtained from subjects who did not fit the Prati criteria (19.4 U/l ± 1.8, p = 0.04 for women and 29.0 U/l ± 12.1, p =",
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T1 - Revising the upper limit of normal for levels of serum alanine aminotransferase in a middle eastern population with normal liver histology

AU - Al-Hamoudi, Waleed

AU - Ali, Safiyya

AU - Hegab, Bassem

AU - Elsiesy, Hussien

AU - Hashim, Almoutaz

AU - Al-Sofayan, Mohammed

AU - Khalaf, Hatem

AU - Al-Bahili, Hamad

AU - Al-Masri, Nasser

AU - Al-Sebayel, Mohammed

AU - Broering, Dieter

AU - Abdo, Ayman

AU - Alqahtani, Saleh Ali

AU - Abaalkhail, Faisal

PY - 2013/8

Y1 - 2013/8

N2 - Background: Recently, the upper limits of normal (ULN) for alanine-aminotransferase (ALT) has been recommended to be lowered to ≤30 U/l in men and ≤19 U/l in women. Aim: To evaluate the ALT concentrations in a healthy Middle Eastern population with biopsy-proven normal liver tissue. Methods: ALT values were calculated from 175 consecutive Saudi potential living liver donors who underwent a liver biopsy as part of a stepwise pretransplant workup. Results: The mean age of the 110 potential donors with normal liver histology was 27 ± 6.2 years for men and 38.6 ± 7.1 years for women. The mean body mass index (BMI) levels were 23.0 ± 3.5 kg/m 2 for men and 24.7 ± 3.25 kg/m2 for women, and the ALT levels were higher in male patients (22.6 ± 9 vs. 16.4 U/l ± 8, p value = 0.003). Multivariate linear regression showed that BMI and sex were independent variables that were positively associated with the levels of ALT (p <0.0001). Moreover, when we analyzed donors according to the Prati criteria, 63 (36.0 %) of the individuals were classified into this subgroup. The mean ALT concentration was 12.9 U/l ± 4.5 in women and 19.7 U/l ± 6.9 in men, and these values were significantly lower than those obtained from subjects who did not fit the Prati criteria (19.4 U/l ± 1.8, p = 0.04 for women and 29.0 U/l ± 12.1, p =

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KW - Steatosis

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