Abstract
Background: Recently, the upper limits of normal (ULN) for alanine-aminotransferase (ALT) has been recommended to be lowered to ≤30 U/l in men and ≤19 U/l in women. Aim: To evaluate the ALT concentrations in a healthy Middle Eastern population with biopsy-proven normal liver tissue. Methods: ALT values were calculated from 175 consecutive Saudi potential living liver donors who underwent a liver biopsy as part of a stepwise pretransplant workup. Results: The mean age of the 110 potential donors with normal liver histology was 27 ± 6.2 years for men and 38.6 ± 7.1 years for women. The mean body mass index (BMI) levels were 23.0 ± 3.5 kg/m 2 for men and 24.7 ± 3.25 kg/m2 for women, and the ALT levels were higher in male patients (22.6 ± 9 vs. 16.4 U/l ± 8, p value = 0.003). Multivariate linear regression showed that BMI and sex were independent variables that were positively associated with the levels of ALT (p <0.0001). Moreover, when we analyzed donors according to the Prati criteria, 63 (36.0 %) of the individuals were classified into this subgroup. The mean ALT concentration was 12.9 U/l ± 4.5 in women and 19.7 U/l ± 6.9 in men, and these values were significantly lower than those obtained from subjects who did not fit the Prati criteria (19.4 U/l ± 1.8, p = 0.04 for women and 29.0 U/l ± 12.1, p =
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2369-2375 |
| Number of pages | 7 |
| Journal | Digestive Diseases and Sciences |
| Volume | 58 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2013 |
| Externally published | Yes |
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Keywords
- Alanine aminotransferase
- Liver biopsy
- Steatosis
- Upper limit of normal
ASJC Scopus subject areas
- Gastroenterology
- Physiology
Cite this
Revising the upper limit of normal for levels of serum alanine aminotransferase in a middle eastern population with normal liver histology. / Al-Hamoudi, Waleed; Ali, Safiyya; Hegab, Bassem; Elsiesy, Hussien; Hashim, Almoutaz; Al-Sofayan, Mohammed; Khalaf, Hatem; Al-Bahili, Hamad; Al-Masri, Nasser; Al-Sebayel, Mohammed; Broering, Dieter; Abdo, Ayman; Alqahtani, Saleh Ali; Abaalkhail, Faisal.
In: Digestive Diseases and Sciences, Vol. 58, No. 8, 08.2013, p. 2369-2375.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Revising the upper limit of normal for levels of serum alanine aminotransferase in a middle eastern population with normal liver histology
AU - Al-Hamoudi, Waleed
AU - Ali, Safiyya
AU - Hegab, Bassem
AU - Elsiesy, Hussien
AU - Hashim, Almoutaz
AU - Al-Sofayan, Mohammed
AU - Khalaf, Hatem
AU - Al-Bahili, Hamad
AU - Al-Masri, Nasser
AU - Al-Sebayel, Mohammed
AU - Broering, Dieter
AU - Abdo, Ayman
AU - Alqahtani, Saleh Ali
AU - Abaalkhail, Faisal
PY - 2013/8
Y1 - 2013/8
N2 - Background: Recently, the upper limits of normal (ULN) for alanine-aminotransferase (ALT) has been recommended to be lowered to ≤30 U/l in men and ≤19 U/l in women. Aim: To evaluate the ALT concentrations in a healthy Middle Eastern population with biopsy-proven normal liver tissue. Methods: ALT values were calculated from 175 consecutive Saudi potential living liver donors who underwent a liver biopsy as part of a stepwise pretransplant workup. Results: The mean age of the 110 potential donors with normal liver histology was 27 ± 6.2 years for men and 38.6 ± 7.1 years for women. The mean body mass index (BMI) levels were 23.0 ± 3.5 kg/m 2 for men and 24.7 ± 3.25 kg/m2 for women, and the ALT levels were higher in male patients (22.6 ± 9 vs. 16.4 U/l ± 8, p value = 0.003). Multivariate linear regression showed that BMI and sex were independent variables that were positively associated with the levels of ALT (p <0.0001). Moreover, when we analyzed donors according to the Prati criteria, 63 (36.0 %) of the individuals were classified into this subgroup. The mean ALT concentration was 12.9 U/l ± 4.5 in women and 19.7 U/l ± 6.9 in men, and these values were significantly lower than those obtained from subjects who did not fit the Prati criteria (19.4 U/l ± 1.8, p = 0.04 for women and 29.0 U/l ± 12.1, p =
AB - Background: Recently, the upper limits of normal (ULN) for alanine-aminotransferase (ALT) has been recommended to be lowered to ≤30 U/l in men and ≤19 U/l in women. Aim: To evaluate the ALT concentrations in a healthy Middle Eastern population with biopsy-proven normal liver tissue. Methods: ALT values were calculated from 175 consecutive Saudi potential living liver donors who underwent a liver biopsy as part of a stepwise pretransplant workup. Results: The mean age of the 110 potential donors with normal liver histology was 27 ± 6.2 years for men and 38.6 ± 7.1 years for women. The mean body mass index (BMI) levels were 23.0 ± 3.5 kg/m 2 for men and 24.7 ± 3.25 kg/m2 for women, and the ALT levels were higher in male patients (22.6 ± 9 vs. 16.4 U/l ± 8, p value = 0.003). Multivariate linear regression showed that BMI and sex were independent variables that were positively associated with the levels of ALT (p <0.0001). Moreover, when we analyzed donors according to the Prati criteria, 63 (36.0 %) of the individuals were classified into this subgroup. The mean ALT concentration was 12.9 U/l ± 4.5 in women and 19.7 U/l ± 6.9 in men, and these values were significantly lower than those obtained from subjects who did not fit the Prati criteria (19.4 U/l ± 1.8, p = 0.04 for women and 29.0 U/l ± 12.1, p =
KW - Alanine aminotransferase
KW - Liver biopsy
KW - Steatosis
KW - Upper limit of normal
UR - http://www.scopus.com/inward/record.url?scp=84881477563&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84881477563&partnerID=8YFLogxK
U2 - 10.1007/s10620-013-2659-0
DO - 10.1007/s10620-013-2659-0
M3 - Article
C2 - 23543089
AN - SCOPUS:84881477563
VL - 58
SP - 2369
EP - 2375
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
SN - 0163-2116
IS - 8
ER -