Revised Structure of Bryostatin 3 and Isolation of the Bryostatin 3 26-Ketone from Bugula neritina

Daniel E. Schaufelberger, Gwendolyn N. Chmurny, John A. Beutler, Mary P. Koleck, A. Belinda Alvarado, Brigitte W. Schaufelberger, Gary M. Muschik

Research output: Contribution to journalArticlepeer-review

Abstract

Bryostatin 3 and the corresponding 26-ketone 5, which represents a new bryostatin, were isolated from the marine bryozoan Bugula neritina (Bugulidae). Spectroscopic data from 2D NMR studies indicate that the structure of bryostatin 3 (3) has to be revised to structure 4. Bryostatin 3 showed [3H]phorbol dibutyrate receptor displacement activity similar to that of bryostatin 1, whereas the corresponding 26-ketone 5 was significantly less active.

Original languageEnglish (US)
Pages (from-to)2895-2900
Number of pages6
JournalJournal of Organic Chemistry
Volume56
Issue number8
DOIs
StatePublished - Apr 1 1991
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint Dive into the research topics of 'Revised Structure of Bryostatin 3 and Isolation of the Bryostatin 3 26-Ketone from Bugula neritina'. Together they form a unique fingerprint.

Cite this