Reviewing HIV-Related Research in Emerging Economies: The Role of Government Reviewing Agencies

Patrina Sexton, Katrina Hui, Donna Hanrahan, Mark Barnes, Jeremy Sugarman, Alex John London, Robert Klitzman

Research output: Contribution to journalArticle

Abstract

Little research has explored the possible effects of government institutions in emerging economies on ethical reviews of multinational research. We conducted semi-structured, in-depth telephone interviews with 15 researchers, Research Ethics Committees (RECs) personnel, and a government agency member involved in multinational HIV Prevention Trials Network (HPTN) research in emerging economies. Ministries of Health (MOH) or other government agencies often play pivotal roles as facilitators or barriers in the research ethics approval process. Government agency RECs reviewing protocols may face particular challenges, as they can lack resources, be poorly organized, have inconsistent review processes and limited expertise, and use differing definitions of national interests, including upholding national reputation and avoiding potential exploitation and stigma of the country's population. The MOH/governmental review body may be affected by power dynamics and politics in study reviews; may consider issues both related and unrelated to research ethics as understood elsewhere; and may prioritize particular diseases, treatments, or interventions over other topics/types of research. Poor communication and deeply-rooted tensions may exist between sponsor and host countries, impeding optimal interactions and reviews. Investigators must understand and plan for the potential effects of governmental agencies on multinational collaborative research, including preserving adequate time for agency review, and contacting these agencies beforehand to address issues that may arise. Better understanding of these issues can aid and advance appropriate global scientific collaboration. Copyright

Original languageEnglish (US)
Pages (from-to)4-14
Number of pages11
JournalDeveloping World Bioethics
Volume16
Issue number1
DOIs
StatePublished - Apr 1 2016

Keywords

  • Emerging Economies
  • Ethics
  • HIV
  • Institutional Review Boards
  • Ministries of Health
  • Research Ethics Committees

ASJC Scopus subject areas

  • Issues, ethics and legal aspects
  • Health(social science)
  • Health Policy

Fingerprint Dive into the research topics of 'Reviewing HIV-Related Research in Emerging Economies: The Role of Government Reviewing Agencies'. Together they form a unique fingerprint.

  • Cite this