Review of the role of potential teratogens in the origin of human nonsyndromic oral clefts

Diego F. Wyszynski, Terri L Beaty

Research output: Contribution to journalArticle

Abstract

Oral clefts are common birth defects affecting approximately 1 every 1,000 caucasian newborns. While many syndromes with cleft lip with or without cleft palate (CL/P) or with cleft palate (CP) are recognized, the majority of oral clefts fall into the category of 'nonsyndromic oral clefts' and the etiology of this group remains incompletely understood. Investigators agree that oral clefts are multifactorial in origin, with both genetic and environmental factors in their etiology. While animal models have identified several teratogens for oral clefts, their precise relevance for humans remains unclear. The goal of this work is to review literature on environmental exposures potentially associated with non-syndromic oral clefts.

Original languageEnglish (US)
Pages (from-to)309-317
Number of pages9
JournalTeratology
Volume53
Issue number5
DOIs
StatePublished - May 1996

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Teratogens
Cleft Palate
Animals
Defects
Cleft Lip
Environmental Exposure
Animal Models
Research Personnel

ASJC Scopus subject areas

  • Developmental Biology
  • Embryology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Review of the role of potential teratogens in the origin of human nonsyndromic oral clefts. / Wyszynski, Diego F.; Beaty, Terri L.

In: Teratology, Vol. 53, No. 5, 05.1996, p. 309-317.

Research output: Contribution to journalArticle

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