Review of microRNA in osteosarcoma and chondrosarcoma

Le Chang, Swati Shrestha, Greg LaChaud, Michelle A. Scott, Aaron W. James

Research output: Contribution to journalReview articlepeer-review

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs, which play a complex role in posttranscriptional gene expression and can theoretically be used as a diagnostic or prognostic tool, or therapeutic target for neoplasia. Despite advances in the diagnosis and treatment of skeletal sarcomas, including osteosarcoma and chondrosarcoma, much remains unknown regarding their underpinning molecular mechanisms. Given the recent increasing knowledge base of miRNA roles in neoplasia, both as oncogenes and tumor suppressor genes, this review will focus on the available literature regarding the expression profiles and potential roles of miRNA in skeletal sarcomas. Although this is an emerging field, miRNA profiling may be of use in clarifying competing diagnoses of skeletal sarcomas and possibly indicate patient risk of resistance to traditional chemotherapeutic agents. While detecting and targeting miRNAs is currently limited to experimental investigations, miRNA may be utilized for future clinical management of skeletal sarcomas.

Original languageEnglish (US)
JournalMedical Oncology
Volume32
Issue number6
DOIs
StatePublished - May 1 2015
Externally publishedYes

Keywords

  • Chondrosarcoma
  • Oncogene
  • Osteosarcoma
  • Skeletal sarcoma
  • Tumor suppressor
  • miRNA
  • microRNA

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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