TY - JOUR
T1 - Review of mass drug administration for malaria and its operational challenges
AU - Newby, Gretchen
AU - Hwang, Jimee
AU - Koita, Kadiatou
AU - Chen, Ingrid
AU - Greenwood, Brian
AU - Von Seidlein, Lorenz
AU - Shanks, G. Dennis
AU - Slutsker, Laurence
AU - Kachur, S. Patrick
AU - Wegbreit, Jennifer
AU - Ippolito, Matthew M.
AU - Poirot, Eugenie
AU - Gosling, Roly
N1 - Publisher Copyright:
Copyright © 2015 by The American Society of Tropical Medicine and Hygiene.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Mass drug administration (MDA) was a component of many malaria programs during the eradication era, but later was seldomly deployed due to concerns regarding efficacy and feasibility and fear of accelerating drug resistance. Recently, however, there has been renewed interest in the role of MDA as an elimination tool. Following a 2013 Cochrane Review that focused on the quantitative effects of malaria MDA, we have conducted a systematic, qualitative review of published, unpublished, and gray literature documenting past MDA experiences. We have also consulted with field experts, using their historical experience to provide an informed, contextual perspective on the role of MDA in malaria elimination. Substantial knowledge gaps remain and more research is necessary, particularly on optimal target population size, methods to improve coverage, and primaquine safety. Despite these gaps, MDA has been used successfully to control and eliminate Plasmodium falciparum and P. vivax malaria in the past, and should be considered as part of a comprehensive malaria elimination strategy in specific settings.
AB - Mass drug administration (MDA) was a component of many malaria programs during the eradication era, but later was seldomly deployed due to concerns regarding efficacy and feasibility and fear of accelerating drug resistance. Recently, however, there has been renewed interest in the role of MDA as an elimination tool. Following a 2013 Cochrane Review that focused on the quantitative effects of malaria MDA, we have conducted a systematic, qualitative review of published, unpublished, and gray literature documenting past MDA experiences. We have also consulted with field experts, using their historical experience to provide an informed, contextual perspective on the role of MDA in malaria elimination. Substantial knowledge gaps remain and more research is necessary, particularly on optimal target population size, methods to improve coverage, and primaquine safety. Despite these gaps, MDA has been used successfully to control and eliminate Plasmodium falciparum and P. vivax malaria in the past, and should be considered as part of a comprehensive malaria elimination strategy in specific settings.
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U2 - 10.4269/ajtmh.14-0254
DO - 10.4269/ajtmh.14-0254
M3 - Review article
C2 - 26013371
AN - SCOPUS:84936991079
SN - 0002-9637
VL - 93
SP - 125
EP - 134
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 1
ER -