TY - JOUR
T1 - Review
T2 - JC virus infection of lymphocytes-revisited
AU - Gallia, G. L.
AU - Houff, S. A.
AU - Major, E. O.
AU - Khalili, K.
N1 - Funding Information:
Received 12 February 1997; revised 10 July 1997. Grant support: NIH (to K.K.). Reprints or correspondence: Dr. Kamel Khalili, Center for NeuroVirology and NeuroOncology, Allegheny University of the Health Sciences, 245 N. 15th St., Mailstop 406, Philadelphia, PA 19102.
PY - 1997
Y1 - 1997
N2 - JC virus (JCV), the causative agent of the fatal human demyelinating disease progressive multifocal leukoencephalopathy (PML), is an opportunistic papovavirus that infects and destroys oligodendrocytes, the myelin-producing cells of the central nervous system. Since its isolation from the brain of a PML patient, JCV has long been classed as a neurotropic virus. Many studies, however, have demonstrated that JCV can infect various other cell types, including immune system cells. Moreover, several recent studies have focused specifically on lymphocytes as a target of JCV. This review chronicles the association of JCV with lymphocytes, including cell type localization, molecular regulation, and viral sequences, and discusses clinical implications of these findings.
AB - JC virus (JCV), the causative agent of the fatal human demyelinating disease progressive multifocal leukoencephalopathy (PML), is an opportunistic papovavirus that infects and destroys oligodendrocytes, the myelin-producing cells of the central nervous system. Since its isolation from the brain of a PML patient, JCV has long been classed as a neurotropic virus. Many studies, however, have demonstrated that JCV can infect various other cell types, including immune system cells. Moreover, several recent studies have focused specifically on lymphocytes as a target of JCV. This review chronicles the association of JCV with lymphocytes, including cell type localization, molecular regulation, and viral sequences, and discusses clinical implications of these findings.
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U2 - 10.1086/514161
DO - 10.1086/514161
M3 - Review article
C2 - 9395374
AN - SCOPUS:0030716946
SN - 0022-1899
VL - 176
SP - 1603
EP - 1609
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -