Abstract
To investigate whether autoimmunity against thyroid antigens is induced or exacerbated by granulocyte-macrophage colony-stimulating factor, thyroid function and thyroid autoantibodies were studied in 14 patients with advanced breast cancer and 11 with soft-tissue sarcoma who received several cycles of doxorubicin and cyclophosphamide plus GM-CSF 250 μg/m2 intravenously daily for 10 days in every 21 day cycle. All patients had normal thyroid function before treatment. In 2 patients with pre-existing thyroid antibodies, thyroid dysfunction developed but disappeared after cessation of GM-CSF. No other autoimmune abnormalities appeared. Stimulation of antigen-presenting cells by GM-CSF may bring about this phenomenon.
Original language | English (US) |
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Pages (from-to) | 541-542 |
Number of pages | 2 |
Journal | The Lancet |
Volume | 338 |
Issue number | 8766 |
DOIs | |
State | Published - Aug 31 1991 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)