Abstract
To investigate whether autoimmunity against thyroid antigens is induced or exacerbated by granulocyte-macrophage colony-stimulating factor, thyroid function and thyroid autoantibodies were studied in 14 patients with advanced breast cancer and 11 with soft-tissue sarcoma who received several cycles of doxorubicin and cyclophosphamide plus GM-CSF 250 μg/m2 intravenously daily for 10 days in every 21 day cycle. All patients had normal thyroid function before treatment. In 2 patients with pre-existing thyroid antibodies, thyroid dysfunction developed but disappeared after cessation of GM-CSF. No other autoimmune abnormalities appeared. Stimulation of antigen-presenting cells by GM-CSF may bring about this phenomenon.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 541-542 |
| Number of pages | 2 |
| Journal | The Lancet |
| Volume | 338 |
| Issue number | 8766 |
| DOIs | |
| State | Published - Aug 31 1991 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Reversible thyroid dysfunction during treatment with GM-CSF. / Hoekman, K.; Wagstaff, J.; Pinedo, H. M.; von Blomberg-van der Flier, B. M E; Drexhage, H. A.
In: The Lancet, Vol. 338, No. 8766, 31.08.1991, p. 541-542.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reversible thyroid dysfunction during treatment with GM-CSF
AU - Hoekman, K.
AU - Wagstaff, J.
AU - Pinedo, H. M.
AU - von Blomberg-van der Flier, B. M E
AU - Drexhage, H. A.
PY - 1991/8/31
Y1 - 1991/8/31
N2 - To investigate whether autoimmunity against thyroid antigens is induced or exacerbated by granulocyte-macrophage colony-stimulating factor, thyroid function and thyroid autoantibodies were studied in 14 patients with advanced breast cancer and 11 with soft-tissue sarcoma who received several cycles of doxorubicin and cyclophosphamide plus GM-CSF 250 μg/m2 intravenously daily for 10 days in every 21 day cycle. All patients had normal thyroid function before treatment. In 2 patients with pre-existing thyroid antibodies, thyroid dysfunction developed but disappeared after cessation of GM-CSF. No other autoimmune abnormalities appeared. Stimulation of antigen-presenting cells by GM-CSF may bring about this phenomenon.
AB - To investigate whether autoimmunity against thyroid antigens is induced or exacerbated by granulocyte-macrophage colony-stimulating factor, thyroid function and thyroid autoantibodies were studied in 14 patients with advanced breast cancer and 11 with soft-tissue sarcoma who received several cycles of doxorubicin and cyclophosphamide plus GM-CSF 250 μg/m2 intravenously daily for 10 days in every 21 day cycle. All patients had normal thyroid function before treatment. In 2 patients with pre-existing thyroid antibodies, thyroid dysfunction developed but disappeared after cessation of GM-CSF. No other autoimmune abnormalities appeared. Stimulation of antigen-presenting cells by GM-CSF may bring about this phenomenon.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025916048&partnerID=8YFLogxK
U2 - 10.1016/0140-6736(91)91103-2
DO - 10.1016/0140-6736(91)91103-2
M3 - Article
C2 - 1678803
AN - SCOPUS:0025916048
VL - 338
SP - 541
EP - 542
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 8766
ER -