Reversible thyroid dysfunction during treatment with GM-CSF

K. Hoekman; J. Wagstaff; H. M. Pinedo; B. M E von Blomberg-van der Flier; H. A. Drexhage

doi:10.1016/0140-6736(91)91103-2

Reversible thyroid dysfunction during treatment with GM-CSF

K. Hoekman, J. Wagstaff, H. M. Pinedo, B. M E von Blomberg-van der Flier, H. A. Drexhage

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Abstract

To investigate whether autoimmunity against thyroid antigens is induced or exacerbated by granulocyte-macrophage colony-stimulating factor, thyroid function and thyroid autoantibodies were studied in 14 patients with advanced breast cancer and 11 with soft-tissue sarcoma who received several cycles of doxorubicin and cyclophosphamide plus GM-CSF 250 μg/m² intravenously daily for 10 days in every 21 day cycle. All patients had normal thyroid function before treatment. In 2 patients with pre-existing thyroid antibodies, thyroid dysfunction developed but disappeared after cessation of GM-CSF. No other autoimmune abnormalities appeared. Stimulation of antigen-presenting cells by GM-CSF may bring about this phenomenon.

Original language	English (US)
Pages (from-to)	541-542
Number of pages	2
Journal	The Lancet
Volume	338
Issue number	8766
DOIs	https://doi.org/10.1016/0140-6736(91)91103-2
State	Published - Aug 31 1991
Externally published	Yes

ASJC Scopus subject areas

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abstract = "To investigate whether autoimmunity against thyroid antigens is induced or exacerbated by granulocyte-macrophage colony-stimulating factor, thyroid function and thyroid autoantibodies were studied in 14 patients with advanced breast cancer and 11 with soft-tissue sarcoma who received several cycles of doxorubicin and cyclophosphamide plus GM-CSF 250 μg/m2 intravenously daily for 10 days in every 21 day cycle. All patients had normal thyroid function before treatment. In 2 patients with pre-existing thyroid antibodies, thyroid dysfunction developed but disappeared after cessation of GM-CSF. No other autoimmune abnormalities appeared. Stimulation of antigen-presenting cells by GM-CSF may bring about this phenomenon.",

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AU - Wagstaff, J.

AU - Pinedo, H. M.

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AU - Drexhage, H. A.

PY - 1991/8/31

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AB - To investigate whether autoimmunity against thyroid antigens is induced or exacerbated by granulocyte-macrophage colony-stimulating factor, thyroid function and thyroid autoantibodies were studied in 14 patients with advanced breast cancer and 11 with soft-tissue sarcoma who received several cycles of doxorubicin and cyclophosphamide plus GM-CSF 250 μg/m2 intravenously daily for 10 days in every 21 day cycle. All patients had normal thyroid function before treatment. In 2 patients with pre-existing thyroid antibodies, thyroid dysfunction developed but disappeared after cessation of GM-CSF. No other autoimmune abnormalities appeared. Stimulation of antigen-presenting cells by GM-CSF may bring about this phenomenon.

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Reversible thyroid dysfunction during treatment with GM-CSF

Abstract

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