Reversible thyroid dysfunction during treatment with GM-CSF

K. Hoekman; J. Wagstaff; H. M. Pinedo; B. M E von Blomberg-van der Flier; H. A. Drexhage

doi:10.1016/0140-6736(91)91103-2

Reversible thyroid dysfunction during treatment with GM-CSF

K. Hoekman, J. Wagstaff, H. M. Pinedo, B. M E von Blomberg-van der Flier, H. A. Drexhage

Research output: Contribution to journal › Article › peer-review

Abstract

To investigate whether autoimmunity against thyroid antigens is induced or exacerbated by granulocyte-macrophage colony-stimulating factor, thyroid function and thyroid autoantibodies were studied in 14 patients with advanced breast cancer and 11 with soft-tissue sarcoma who received several cycles of doxorubicin and cyclophosphamide plus GM-CSF 250 μg/m² intravenously daily for 10 days in every 21 day cycle. All patients had normal thyroid function before treatment. In 2 patients with pre-existing thyroid antibodies, thyroid dysfunction developed but disappeared after cessation of GM-CSF. No other autoimmune abnormalities appeared. Stimulation of antigen-presenting cells by GM-CSF may bring about this phenomenon.

Original language	English (US)
Pages (from-to)	541-542
Number of pages	2
Journal	The Lancet
Volume	338
Issue number	8766
DOIs	https://doi.org/10.1016/0140-6736(91)91103-2
State	Published - Aug 31 1991
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1016/0140-6736(91)91103-2

Cite this

@article{21b5d3a6838b412fbe744cca2bb3d3b2,

title = "Reversible thyroid dysfunction during treatment with GM-CSF",

abstract = "To investigate whether autoimmunity against thyroid antigens is induced or exacerbated by granulocyte-macrophage colony-stimulating factor, thyroid function and thyroid autoantibodies were studied in 14 patients with advanced breast cancer and 11 with soft-tissue sarcoma who received several cycles of doxorubicin and cyclophosphamide plus GM-CSF 250 μg/m2 intravenously daily for 10 days in every 21 day cycle. All patients had normal thyroid function before treatment. In 2 patients with pre-existing thyroid antibodies, thyroid dysfunction developed but disappeared after cessation of GM-CSF. No other autoimmune abnormalities appeared. Stimulation of antigen-presenting cells by GM-CSF may bring about this phenomenon.",

author = "K. Hoekman and J. Wagstaff and Pinedo, {H. M.} and {von Blomberg-van der Flier}, {B. M E} and Drexhage, {H. A.}",

year = "1991",

month = aug,

day = "31",

doi = "10.1016/0140-6736(91)91103-2",

language = "English (US)",

volume = "338",

pages = "541--542",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier Limited",

number = "8766",

}

TY - JOUR

T1 - Reversible thyroid dysfunction during treatment with GM-CSF

AU - Hoekman, K.

AU - Wagstaff, J.

AU - Pinedo, H. M.

AU - von Blomberg-van der Flier, B. M E

AU - Drexhage, H. A.

PY - 1991/8/31

Y1 - 1991/8/31

N2 - To investigate whether autoimmunity against thyroid antigens is induced or exacerbated by granulocyte-macrophage colony-stimulating factor, thyroid function and thyroid autoantibodies were studied in 14 patients with advanced breast cancer and 11 with soft-tissue sarcoma who received several cycles of doxorubicin and cyclophosphamide plus GM-CSF 250 μg/m2 intravenously daily for 10 days in every 21 day cycle. All patients had normal thyroid function before treatment. In 2 patients with pre-existing thyroid antibodies, thyroid dysfunction developed but disappeared after cessation of GM-CSF. No other autoimmune abnormalities appeared. Stimulation of antigen-presenting cells by GM-CSF may bring about this phenomenon.

AB - To investigate whether autoimmunity against thyroid antigens is induced or exacerbated by granulocyte-macrophage colony-stimulating factor, thyroid function and thyroid autoantibodies were studied in 14 patients with advanced breast cancer and 11 with soft-tissue sarcoma who received several cycles of doxorubicin and cyclophosphamide plus GM-CSF 250 μg/m2 intravenously daily for 10 days in every 21 day cycle. All patients had normal thyroid function before treatment. In 2 patients with pre-existing thyroid antibodies, thyroid dysfunction developed but disappeared after cessation of GM-CSF. No other autoimmune abnormalities appeared. Stimulation of antigen-presenting cells by GM-CSF may bring about this phenomenon.

UR - http://www.scopus.com/inward/record.url?scp=0025916048&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025916048&partnerID=8YFLogxK

U2 - 10.1016/0140-6736(91)91103-2

DO - 10.1016/0140-6736(91)91103-2

M3 - Article

C2 - 1678803

AN - SCOPUS:0025916048

VL - 338

SP - 541

EP - 542

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 8766

ER -

Reversible thyroid dysfunction during treatment with GM-CSF

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this