Reversible thyroid dysfunction during treatment with GM-CSF

K. Hoekman, J. Wagstaff, H. M. Pinedo, B. M E von Blomberg-van der Flier, H. A. Drexhage

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


To investigate whether autoimmunity against thyroid antigens is induced or exacerbated by granulocyte-macrophage colony-stimulating factor, thyroid function and thyroid autoantibodies were studied in 14 patients with advanced breast cancer and 11 with soft-tissue sarcoma who received several cycles of doxorubicin and cyclophosphamide plus GM-CSF 250 μg/m2 intravenously daily for 10 days in every 21 day cycle. All patients had normal thyroid function before treatment. In 2 patients with pre-existing thyroid antibodies, thyroid dysfunction developed but disappeared after cessation of GM-CSF. No other autoimmune abnormalities appeared. Stimulation of antigen-presenting cells by GM-CSF may bring about this phenomenon.

Original languageEnglish (US)
Pages (from-to)541-542
Number of pages2
JournalThe Lancet
Issue number8766
StatePublished - Aug 31 1991
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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