Reversible Renovascular Hypertension and Renal Arterial Pressure (38231)

Hitoshi Tagawa, Frank D. Gutmann, Edgar Haber, Edward Miller, Alan I. Samuels, A. Clifford Barger

Research output: Contribution to journalArticle

Abstract

In the conscious, trained dog we have noted an increase in apparent renin secretion following renal artery constriction and reduction of renal arterial pressure, with little or no change in renal blood flow, and without significant change in distribution of cortical blood flow. Within 2-5 days, however, basal renin secretion rates declined toward normal despite maintained renal arterial hypotension; body fluid volume was increased. A highly significant correlation between systemic blood pressure and body wt was noted. With release of the cuff, a natriuresis and diuresis was observed, with a return of body weight and hematocrit to normal within the first 24-48 hr. However, despite the decrease in body fluid, and the decrease in renin secretion and PRA, blood pressure returned to control level more slowly, suggesting a resetting of the baroreceptor reflex.

Original languageEnglish (US)
Pages (from-to)975-982
Number of pages8
JournalProceedings of the Society for Experimental Biology and Medicine
Volume146
Issue number4
DOIs
StatePublished - 1974
Externally publishedYes

Fingerprint

Renovascular Hypertension
Renin
Arterial Pressure
Body fluids
Blood pressure
Body Fluids
Kidney
Blood
Blood Pressure
Natriuresis
Baroreflex
Renal Circulation
Diuresis
Level control
Renal Artery
Hematocrit
Constriction
Hypotension
Body Weight
Dogs

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Reversible Renovascular Hypertension and Renal Arterial Pressure (38231). / Tagawa, Hitoshi; Gutmann, Frank D.; Haber, Edgar; Miller, Edward; Samuels, Alan I.; Barger, A. Clifford.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 146, No. 4, 1974, p. 975-982.

Research output: Contribution to journalArticle

Tagawa, Hitoshi ; Gutmann, Frank D. ; Haber, Edgar ; Miller, Edward ; Samuels, Alan I. ; Barger, A. Clifford. / Reversible Renovascular Hypertension and Renal Arterial Pressure (38231). In: Proceedings of the Society for Experimental Biology and Medicine. 1974 ; Vol. 146, No. 4. pp. 975-982.
@article{d26a9f713947490fb4930d3dc7116a23,
title = "Reversible Renovascular Hypertension and Renal Arterial Pressure (38231)",
abstract = "In the conscious, trained dog we have noted an increase in apparent renin secretion following renal artery constriction and reduction of renal arterial pressure, with little or no change in renal blood flow, and without significant change in distribution of cortical blood flow. Within 2-5 days, however, basal renin secretion rates declined toward normal despite maintained renal arterial hypotension; body fluid volume was increased. A highly significant correlation between systemic blood pressure and body wt was noted. With release of the cuff, a natriuresis and diuresis was observed, with a return of body weight and hematocrit to normal within the first 24-48 hr. However, despite the decrease in body fluid, and the decrease in renin secretion and PRA, blood pressure returned to control level more slowly, suggesting a resetting of the baroreceptor reflex.",
author = "Hitoshi Tagawa and Gutmann, {Frank D.} and Edgar Haber and Edward Miller and Samuels, {Alan I.} and Barger, {A. Clifford}",
year = "1974",
doi = "10.3181/00379727-146-38231",
language = "English (US)",
volume = "146",
pages = "975--982",
journal = "Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)",
issn = "0037-9727",
publisher = "Society for Experimental Biology and Medicine",
number = "4",

}

TY - JOUR

T1 - Reversible Renovascular Hypertension and Renal Arterial Pressure (38231)

AU - Tagawa, Hitoshi

AU - Gutmann, Frank D.

AU - Haber, Edgar

AU - Miller, Edward

AU - Samuels, Alan I.

AU - Barger, A. Clifford

PY - 1974

Y1 - 1974

N2 - In the conscious, trained dog we have noted an increase in apparent renin secretion following renal artery constriction and reduction of renal arterial pressure, with little or no change in renal blood flow, and without significant change in distribution of cortical blood flow. Within 2-5 days, however, basal renin secretion rates declined toward normal despite maintained renal arterial hypotension; body fluid volume was increased. A highly significant correlation between systemic blood pressure and body wt was noted. With release of the cuff, a natriuresis and diuresis was observed, with a return of body weight and hematocrit to normal within the first 24-48 hr. However, despite the decrease in body fluid, and the decrease in renin secretion and PRA, blood pressure returned to control level more slowly, suggesting a resetting of the baroreceptor reflex.

AB - In the conscious, trained dog we have noted an increase in apparent renin secretion following renal artery constriction and reduction of renal arterial pressure, with little or no change in renal blood flow, and without significant change in distribution of cortical blood flow. Within 2-5 days, however, basal renin secretion rates declined toward normal despite maintained renal arterial hypotension; body fluid volume was increased. A highly significant correlation between systemic blood pressure and body wt was noted. With release of the cuff, a natriuresis and diuresis was observed, with a return of body weight and hematocrit to normal within the first 24-48 hr. However, despite the decrease in body fluid, and the decrease in renin secretion and PRA, blood pressure returned to control level more slowly, suggesting a resetting of the baroreceptor reflex.

UR - http://www.scopus.com/inward/record.url?scp=0016263080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016263080&partnerID=8YFLogxK

U2 - 10.3181/00379727-146-38231

DO - 10.3181/00379727-146-38231

M3 - Article

C2 - 4424032

AN - SCOPUS:0016263080

VL - 146

SP - 975

EP - 982

JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

SN - 0037-9727

IS - 4

ER -