TY - JOUR
T1 - Reversible Renovascular Hypertension and Renal Arterial Pressure (38231)
AU - Tagawa, Hitoshi
AU - Gutmann, Frank D.
AU - Haber, Edgar
AU - Miller, Edward D.
AU - Samuels, Alan I.
AU - Barger, A. Clifford
N1 - Funding Information:
This research was supported in part by a grant from the United States Public Health Service for a Specialized Center of Research in Hypertension (HL 14150).
PY - 1974/9
Y1 - 1974/9
N2 - In the conscious, trained dog we have noted an increase in apparent renin secretion following renal artery constriction and reduction of renal arterial pressure, with little or no change in renal blood flow, and without significant change in distribution of cortical blood flow. Within 2-5 days, however, basal renin secretion rates declined toward normal despite maintained renal arterial hypotension; body fluid volume was increased. A highly significant correlation between systemic blood pressure and body wt was noted. With release of the cuff, a natriuresis and diuresis was observed, with a return of body weight and hematocrit to normal within the first 24-48 hr. However, despite the decrease in body fluid, and the decrease in renin secretion and PRA, blood pressure returned to control level more slowly, suggesting a resetting of the baroreceptor reflex.
AB - In the conscious, trained dog we have noted an increase in apparent renin secretion following renal artery constriction and reduction of renal arterial pressure, with little or no change in renal blood flow, and without significant change in distribution of cortical blood flow. Within 2-5 days, however, basal renin secretion rates declined toward normal despite maintained renal arterial hypotension; body fluid volume was increased. A highly significant correlation between systemic blood pressure and body wt was noted. With release of the cuff, a natriuresis and diuresis was observed, with a return of body weight and hematocrit to normal within the first 24-48 hr. However, despite the decrease in body fluid, and the decrease in renin secretion and PRA, blood pressure returned to control level more slowly, suggesting a resetting of the baroreceptor reflex.
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U2 - 10.3181/00379727-146-38231
DO - 10.3181/00379727-146-38231
M3 - Article
C2 - 4424032
AN - SCOPUS:0016263080
SN - 0037-9727
VL - 146
SP - 975
EP - 982
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 4
ER -