Reversible cardiomyopathy caused by administration of interferon α

Aarif Y. Khakoo; Marc K. Halushka; J. Eduardo Rame; E. Rene Rodriguez; Edward K. Kasper; Daniel P. Judge

doi:10.1038/ncpcardio0069

Reversible cardiomyopathy caused by administration of interferon α

Aarif Y. Khakoo, Marc K. Halushka, J. Eduardo Rame, E. Rene Rodriguez, Edward K. Kasper, Daniel P. Judge

School of Medicine

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Background: A 56-year-old man with normal cardiac function received treatment with interferon α-2b for malignant melanoma. Eight months after the initiation of therapy he developed fatigue and dyspnea on exertion. Two months later, he was admitted to hospital with ORTHOPNEA, worsening dyspnea and cough. Physical examination findings were consistent with congestive heart failure. Laboratory studies were notable for hypothyroidism. Echocardiography revealed severe, global left-ventricular dysfunction. Investigations: Echocardiogram, electrocardiogram, serum chemistries, coronary angiography, right-heart and left-heart catheterization and endomyocardial biopsy. Diagnosis: Interferon α-2b-induced cardiomyopathy. Management: Intravenous dobutamine and dopamine for cardiogenic shock and discontinuation of interferon α-2b.

Original language	English (US)
Pages (from-to)	53-57
Number of pages	5
Journal	Nature Clinical Practice Cardiovascular Medicine
Volume	2
Issue number	1
DOIs	https://doi.org/10.1038/ncpcardio0069
State	Published - Jan 2005

Keywords

Cardiomyopathy
Endomyocardial biopsy
Interferon α
Myocardial inflammation

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1038/ncpcardio0069

Cite this

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title = "Reversible cardiomyopathy caused by administration of interferon α",

abstract = "Background: A 56-year-old man with normal cardiac function received treatment with interferon α-2b for malignant melanoma. Eight months after the initiation of therapy he developed fatigue and dyspnea on exertion. Two months later, he was admitted to hospital with ORTHOPNEA, worsening dyspnea and cough. Physical examination findings were consistent with congestive heart failure. Laboratory studies were notable for hypothyroidism. Echocardiography revealed severe, global left-ventricular dysfunction. Investigations: Echocardiogram, electrocardiogram, serum chemistries, coronary angiography, right-heart and left-heart catheterization and endomyocardial biopsy. Diagnosis: Interferon α-2b-induced cardiomyopathy. Management: Intravenous dobutamine and dopamine for cardiogenic shock and discontinuation of interferon α-2b.",

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AU - Khakoo, Aarif Y.

AU - Halushka, Marc K.

AU - Rame, J. Eduardo

AU - Rodriguez, E. Rene

AU - Kasper, Edward K.

AU - Judge, Daniel P.

PY - 2005/1

Y1 - 2005/1

N2 - Background: A 56-year-old man with normal cardiac function received treatment with interferon α-2b for malignant melanoma. Eight months after the initiation of therapy he developed fatigue and dyspnea on exertion. Two months later, he was admitted to hospital with ORTHOPNEA, worsening dyspnea and cough. Physical examination findings were consistent with congestive heart failure. Laboratory studies were notable for hypothyroidism. Echocardiography revealed severe, global left-ventricular dysfunction. Investigations: Echocardiogram, electrocardiogram, serum chemistries, coronary angiography, right-heart and left-heart catheterization and endomyocardial biopsy. Diagnosis: Interferon α-2b-induced cardiomyopathy. Management: Intravenous dobutamine and dopamine for cardiogenic shock and discontinuation of interferon α-2b.

AB - Background: A 56-year-old man with normal cardiac function received treatment with interferon α-2b for malignant melanoma. Eight months after the initiation of therapy he developed fatigue and dyspnea on exertion. Two months later, he was admitted to hospital with ORTHOPNEA, worsening dyspnea and cough. Physical examination findings were consistent with congestive heart failure. Laboratory studies were notable for hypothyroidism. Echocardiography revealed severe, global left-ventricular dysfunction. Investigations: Echocardiogram, electrocardiogram, serum chemistries, coronary angiography, right-heart and left-heart catheterization and endomyocardial biopsy. Diagnosis: Interferon α-2b-induced cardiomyopathy. Management: Intravenous dobutamine and dopamine for cardiogenic shock and discontinuation of interferon α-2b.

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KW - Endomyocardial biopsy

KW - Interferon α

KW - Myocardial inflammation

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Reversible cardiomyopathy caused by administration of interferon α

Abstract

Keywords

ASJC Scopus subject areas

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