Reversible cardiac dysfunction associated with pandemic 2009 influenza A(H1N1)

Seth Martin, Caroline L. Hollingsworth, Stephanie G. Norfolk, Cameron R. Wolfe, John W. Hollingsworth

Research output: Contribution to journalArticle

Abstract

Historical influenza A epidemics have carried elevated rates of cardiovascular disease, including transient cardiac dysfunction. Whether such an association holds for the novel influenza A strain, pandemic 2009 influenza A(H1N1) [A(H1N1)], remains unknown. We report an index case of transient cardiac dysfunction associated with A(H1N1) infection. Next, we reviewed 123 sequential cases of patients hospitalized with pandemic A(H1N1) at a single academic medical center in the United States from April 1, 2009, through October 31, 2009. We identified that 4.9%(6/123) of patients had either new or worsened left ventricular dysfunction. These cases ranged in age from 23 to 51 years, and all had preexisting medical conditions. ICU level care was required in 83%(5/6) of the cases. Sixty-seven percent (4/6) of the cases had follow-up echocardiograms, and left ventricular function improved in all four. We conclude that potentially reversible cardiac dysfunction is a relatively common complication associated with hospitalized pandemic A(H1N1) influenza.

Original languageEnglish (US)
Pages (from-to)1195-1197
Number of pages3
JournalChest
Volume137
Issue number5
DOIs
StatePublished - May 1 2010
Externally publishedYes

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Pandemics
Human Influenza
Preexisting Condition Coverage
Left Ventricular Dysfunction
Left Ventricular Function
Cardiovascular Diseases
Infection

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Martin, S., Hollingsworth, C. L., Norfolk, S. G., Wolfe, C. R., & Hollingsworth, J. W. (2010). Reversible cardiac dysfunction associated with pandemic 2009 influenza A(H1N1). Chest, 137(5), 1195-1197. https://doi.org/10.1378/chest.10-0032

Reversible cardiac dysfunction associated with pandemic 2009 influenza A(H1N1). / Martin, Seth; Hollingsworth, Caroline L.; Norfolk, Stephanie G.; Wolfe, Cameron R.; Hollingsworth, John W.

In: Chest, Vol. 137, No. 5, 01.05.2010, p. 1195-1197.

Research output: Contribution to journalArticle

Martin, S, Hollingsworth, CL, Norfolk, SG, Wolfe, CR & Hollingsworth, JW 2010, 'Reversible cardiac dysfunction associated with pandemic 2009 influenza A(H1N1)', Chest, vol. 137, no. 5, pp. 1195-1197. https://doi.org/10.1378/chest.10-0032
Martin S, Hollingsworth CL, Norfolk SG, Wolfe CR, Hollingsworth JW. Reversible cardiac dysfunction associated with pandemic 2009 influenza A(H1N1). Chest. 2010 May 1;137(5):1195-1197. https://doi.org/10.1378/chest.10-0032
Martin, Seth ; Hollingsworth, Caroline L. ; Norfolk, Stephanie G. ; Wolfe, Cameron R. ; Hollingsworth, John W. / Reversible cardiac dysfunction associated with pandemic 2009 influenza A(H1N1). In: Chest. 2010 ; Vol. 137, No. 5. pp. 1195-1197.
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