TY - JOUR
T1 - Reversible cardiac dysfunction associated with pandemic 2009 influenza A(H1N1)
AU - Martin, Seth S.
AU - Hollingsworth, Caroline L.
AU - Norfolk, Stephanie G.
AU - Wolfe, Cameron R.
AU - Hollingsworth, John W.
N1 - Funding Information:
Funding/Support: This work was supported by the National Institutes of Health [Grants ES16126 , ES16659 , AI81672 ].
PY - 2010/5/1
Y1 - 2010/5/1
N2 - Historical influenza A epidemics have carried elevated rates of cardiovascular disease, including transient cardiac dysfunction. Whether such an association holds for the novel influenza A strain, pandemic 2009 influenza A(H1N1) [A(H1N1)], remains unknown. We report an index case of transient cardiac dysfunction associated with A(H1N1) infection. Next, we reviewed 123 sequential cases of patients hospitalized with pandemic A(H1N1) at a single academic medical center in the United States from April 1, 2009, through October 31, 2009. We identified that 4.9%(6/123) of patients had either new or worsened left ventricular dysfunction. These cases ranged in age from 23 to 51 years, and all had preexisting medical conditions. ICU level care was required in 83%(5/6) of the cases. Sixty-seven percent (4/6) of the cases had follow-up echocardiograms, and left ventricular function improved in all four. We conclude that potentially reversible cardiac dysfunction is a relatively common complication associated with hospitalized pandemic A(H1N1) influenza.
AB - Historical influenza A epidemics have carried elevated rates of cardiovascular disease, including transient cardiac dysfunction. Whether such an association holds for the novel influenza A strain, pandemic 2009 influenza A(H1N1) [A(H1N1)], remains unknown. We report an index case of transient cardiac dysfunction associated with A(H1N1) infection. Next, we reviewed 123 sequential cases of patients hospitalized with pandemic A(H1N1) at a single academic medical center in the United States from April 1, 2009, through October 31, 2009. We identified that 4.9%(6/123) of patients had either new or worsened left ventricular dysfunction. These cases ranged in age from 23 to 51 years, and all had preexisting medical conditions. ICU level care was required in 83%(5/6) of the cases. Sixty-seven percent (4/6) of the cases had follow-up echocardiograms, and left ventricular function improved in all four. We conclude that potentially reversible cardiac dysfunction is a relatively common complication associated with hospitalized pandemic A(H1N1) influenza.
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U2 - 10.1378/chest.10-0032
DO - 10.1378/chest.10-0032
M3 - Article
C2 - 20139224
AN - SCOPUS:77951786561
SN - 0012-3692
VL - 137
SP - 1195
EP - 1197
JO - CHEST
JF - CHEST
IS - 5
ER -