Reversible bilateral internuclear ophthalmoplegia associated with FK506

M. M. Lai, J. B. Kerrison, N. R. Miller

Research output: Contribution to journalArticlepeer-review


A 50 year old man developed tonic-clonic seizures while receiving cyclosporin A after orthotopic cardiac transplant. The seizures resolved after cessation of cyclosporin A. Thirteen months later, he developed diplopia from bilateral internuclear ophthalmoplegia while receiving intravenous FK506. A temporal association was found between his symptoms and the serum FK506 concentrations. Withdrawal of the intravenous FK506 led to prompt resolution of the bilateral internuclear ophthalmoplegia.

Original languageEnglish (US)
Pages (from-to)776-778
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number5
StatePublished - May 2004

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health


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