Reverse transcriptase substitution at codons 208 and 228 among treatment-experienced HIV-1 subtype-C-infected indian patients is strongly associated with thymidine analogue mutations

Shanmugam Saravanan, Vidya Madhavan, Sunil S. Solomon, Rami Kantor, David Katzenstein, Sathasivam Sivamalar, Nagalingeswaran Kumarasamy, Davey M. Smith, Kenneth H. Mayer, Suniti Solomon, Pachamuthu Balakrishnan

Research output: Contribution to journalArticlepeer-review

Abstract

In HIV-1 subtype C-infected populations in south India, we searched for novel mutations associated with failing antiretroviral therapy that included nucleoside reverse transcriptase (RT) inhibitors. HIV-1 RT sequences were generated from treated and untreated groups, and each nucleotide position was analyzed with appropriate corrections for multiple testing. We found that nonsynonymous mutations at positions 208 and 228 were strongly associated with the presence of thymidine analogue mutations in the treated group and were not present at all in the naïve group. The role of these substitutions on treatment outcomes and the evolution of drug resistance in HIV-1 subtype C-infected populations warrant further investigation.

Original languageEnglish (US)
Pages (from-to)e26-e27
JournalJournal of acquired immune deficiency syndromes
Volume59
Issue number2
DOIs
StatePublished - Feb 1 2012
Externally publishedYes

Keywords

  • CA
  • San Diego
  • Veterans Affairs Healthcare System

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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