Reversal of the vasospastic component of lupus vasculopathy by infusion of prostaglandin E1

H. W. Hauptman, S. Ruddy, W. N. Roberts

Research output: Contribution to journalArticlepeer-review

Abstract

The responses of 3 patients with systemic lupus erythematosus (SLE) and progressive digital ischemia to intravenous prostaglandin E1 (PGE1) were studied prospectively in an open 3-day trial. All patients were unresponsive to corticosteroids, one had vasculitis proven by biopsy. Digital ischemia diminished in all 3 patients. In one patient, angiograms documented reappearance of a previously obstructed deep palmar arch. Vasospasm plays a role in the outcome of SLE vasculitis even in the absence of Raynaud's phenomenon. As suggested by animal models of necrotizing and leukocytoclastic vasculitis, and by case reports, intravenous PGE1 may be a relatively nontoxic, adjunctive treatment for vasculitis.

Original languageEnglish (US)
Pages (from-to)1747-1752
Number of pages6
JournalJournal of Rheumatology
Volume18
Issue number11
StatePublished - 1991
Externally publishedYes

Keywords

  • prostaglandin E
  • systemic lupus
  • vasculitis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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