Reversal of experimental allergic encephalomyelitis with monoclonal antibody to a T-cell subset marker

Matthew K. Waldor, Subramanian Sriram, Richard Hardy, Leonore A. Herzenberg, Leonard A. Herzenberg, Lewis Lanier, Mae Lim, Lawrence Steinman

Research output: Contribution to journalArticlepeer-review

Abstract

Administration of a monoclonal antibody (GK1.5) that recognizes the L3T4 marker present on helper T cells prevented the development of experimental allergic encephalomyelitis (EAE) in mice. Furthermore, treatment with GK1.5 reversed EAE when the antibody was given to paralyzed animals. In vivo injection of GK1.5 selectively reduced the number of L3T4+ cells in the spleen and the lymph nodes. These results suggest that manipulation of the human equivalent of the murine L3T4+ T-cell subset with monoclonal antibodies may provide effective therapy for certain autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)415-417
Number of pages3
JournalScience
Volume227
Issue number4685
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

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