Retrotransposons Revisited: The Restraint and Rehabilitation of Parasites

Research output: Contribution to journalReview article

Abstract

Retrotransposons, mainly LINEs, SINEs, and endogenous retroviruses, make up roughly 40% of the mammalian genome and have played an important role in genome evolution. Their prevalence in genomes reflects a delicate balance between their further expansion and the restraint imposed by the host. In any human genome only a small number of LINE1s (L1s) are active, moving their own and SINE sequences into new genomic locations and occasionally causing disease. Recent insights and new technologies promise answers to fundamental questions about the biology of transposable elements.

Original languageEnglish (US)
Pages (from-to)23-35
Number of pages13
JournalCell
Volume135
Issue number1
DOIs
StatePublished - Oct 3 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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