TY - JOUR
T1 - Retrotransposons Revisited
T2 - The Restraint and Rehabilitation of Parasites
AU - Goodier, John L.
AU - Kazazian, Haig H.
N1 - Funding Information:
We thank J. Garcia-Perez, J. Meyer, and S. Rangwala for critical review of the manuscript and S. Robinson for assistance with its preparation. This work was supported by NIH/NIGMS grants to H.H.K. and DOD/CDMRP grant BC051386 to J.L.G.
PY - 2008/10/3
Y1 - 2008/10/3
N2 - Retrotransposons, mainly LINEs, SINEs, and endogenous retroviruses, make up roughly 40% of the mammalian genome and have played an important role in genome evolution. Their prevalence in genomes reflects a delicate balance between their further expansion and the restraint imposed by the host. In any human genome only a small number of LINE1s (L1s) are active, moving their own and SINE sequences into new genomic locations and occasionally causing disease. Recent insights and new technologies promise answers to fundamental questions about the biology of transposable elements.
AB - Retrotransposons, mainly LINEs, SINEs, and endogenous retroviruses, make up roughly 40% of the mammalian genome and have played an important role in genome evolution. Their prevalence in genomes reflects a delicate balance between their further expansion and the restraint imposed by the host. In any human genome only a small number of LINE1s (L1s) are active, moving their own and SINE sequences into new genomic locations and occasionally causing disease. Recent insights and new technologies promise answers to fundamental questions about the biology of transposable elements.
UR - http://www.scopus.com/inward/record.url?scp=52949095077&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=52949095077&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2008.09.022
DO - 10.1016/j.cell.2008.09.022
M3 - Review article
C2 - 18854152
AN - SCOPUS:52949095077
SN - 0092-8674
VL - 135
SP - 23
EP - 35
JO - Cell
JF - Cell
IS - 1
ER -