Retrospective study assessing the role of MRI in the diagnostic procedures for early breast carcinoma

A correlation of new foci in the MRI with tumor pathological features

I. Calvo-Plaza, L. Ugidos, C. Miró, P. Quevedo, M. Parras, C. Márquez, J. J. De La Cruz, A. Suárez-Gauthier, F. J. Pérez, M. Herrero, M. Marcos, M. García-Aranda, M. Hidalgo, L. G. Estévez

Research output: Contribution to journalArticle

Abstract

Background: Use of breast magnetic resonance imaging (MRI) to detect breast cancer has generated significant debate. We analyze the role of breast MRI in the detection of additional disease and the need to perform additional biopsies in early breast carcinoma patients. In addition, we correlate the detection of new foci with tumor pathological features. Methods: Early breast carcinoma patients that had undergone an MRI as well as a mammography as diagnostic procedures were included in the study. The following pathologic features were studied: carcinoma type, histological grade, estrogen receptors (ER), progesterone receptors (PR), HER2 and Ki67. Univariate analysis was conducted to ascertain significant correlation among detection of new foci and each of the tumor pathological features. Results: Data from 98 patients have been analyzed: median age 49 years (range 35-79); carcinoma type: (a) infiltrative ductal carcinoma (n = 73, 74 %), (b) infiltrative lobular cancer (n = 12, 12 %), (c) ductal carcinoma in situ (n = 6, 6 %); amplified HER2 (n = 18, 18 %); grade III (n = 33, 33 %); Ki67 ≥ 25 % (n = 33, 33.67 %); positive ER and PR (n = 79, 80 %); triple negative tumors (n = 8, 8 %). MRI detected additional disease in 38 cases (39.58 %), and 20 led to an additional biopsy (20.4 %). Thirty-eight patients (39 %) underwent mastectomy. We found a statistically significant correlation between new foci in MRI and high Ki67 ≥ 25 % (p <0.005). No other statistically significant correlation was established. Conclusion: MRI detected additional disease in 39 % cases, requiring an additional biopsy 20 %. Tumors with high proliferative index were significantly correlated with the detection of new foci in MRI.

Original languageEnglish (US)
Pages (from-to)205-210
Number of pages6
JournalClinical and Translational Oncology
Volume15
Issue number3
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

Retrospective Studies
Magnetic Resonance Imaging
Breast Neoplasms
Neoplasms
Progesterone Receptors
Biopsy
Estrogen Receptors
Breast
Carcinoma
Ductal Carcinoma
Carcinoma, Intraductal, Noninfiltrating
Mastectomy
Mammography

Keywords

  • Additional biopsies in breast cancer
  • Breast cancer
  • Breast MRI
  • Mastectomy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Retrospective study assessing the role of MRI in the diagnostic procedures for early breast carcinoma : A correlation of new foci in the MRI with tumor pathological features. / Calvo-Plaza, I.; Ugidos, L.; Miró, C.; Quevedo, P.; Parras, M.; Márquez, C.; De La Cruz, J. J.; Suárez-Gauthier, A.; Pérez, F. J.; Herrero, M.; Marcos, M.; García-Aranda, M.; Hidalgo, M.; Estévez, L. G.

In: Clinical and Translational Oncology, Vol. 15, No. 3, 2013, p. 205-210.

Research output: Contribution to journalArticle

Calvo-Plaza, I, Ugidos, L, Miró, C, Quevedo, P, Parras, M, Márquez, C, De La Cruz, JJ, Suárez-Gauthier, A, Pérez, FJ, Herrero, M, Marcos, M, García-Aranda, M, Hidalgo, M & Estévez, LG 2013, 'Retrospective study assessing the role of MRI in the diagnostic procedures for early breast carcinoma: A correlation of new foci in the MRI with tumor pathological features', Clinical and Translational Oncology, vol. 15, no. 3, pp. 205-210. https://doi.org/10.1007/s12094-012-0899-7
Calvo-Plaza, I. ; Ugidos, L. ; Miró, C. ; Quevedo, P. ; Parras, M. ; Márquez, C. ; De La Cruz, J. J. ; Suárez-Gauthier, A. ; Pérez, F. J. ; Herrero, M. ; Marcos, M. ; García-Aranda, M. ; Hidalgo, M. ; Estévez, L. G. / Retrospective study assessing the role of MRI in the diagnostic procedures for early breast carcinoma : A correlation of new foci in the MRI with tumor pathological features. In: Clinical and Translational Oncology. 2013 ; Vol. 15, No. 3. pp. 205-210.
@article{024f3ef0420e4e61a70fabe3f1f56a75,
title = "Retrospective study assessing the role of MRI in the diagnostic procedures for early breast carcinoma: A correlation of new foci in the MRI with tumor pathological features",
abstract = "Background: Use of breast magnetic resonance imaging (MRI) to detect breast cancer has generated significant debate. We analyze the role of breast MRI in the detection of additional disease and the need to perform additional biopsies in early breast carcinoma patients. In addition, we correlate the detection of new foci with tumor pathological features. Methods: Early breast carcinoma patients that had undergone an MRI as well as a mammography as diagnostic procedures were included in the study. The following pathologic features were studied: carcinoma type, histological grade, estrogen receptors (ER), progesterone receptors (PR), HER2 and Ki67. Univariate analysis was conducted to ascertain significant correlation among detection of new foci and each of the tumor pathological features. Results: Data from 98 patients have been analyzed: median age 49 years (range 35-79); carcinoma type: (a) infiltrative ductal carcinoma (n = 73, 74 {\%}), (b) infiltrative lobular cancer (n = 12, 12 {\%}), (c) ductal carcinoma in situ (n = 6, 6 {\%}); amplified HER2 (n = 18, 18 {\%}); grade III (n = 33, 33 {\%}); Ki67 ≥ 25 {\%} (n = 33, 33.67 {\%}); positive ER and PR (n = 79, 80 {\%}); triple negative tumors (n = 8, 8 {\%}). MRI detected additional disease in 38 cases (39.58 {\%}), and 20 led to an additional biopsy (20.4 {\%}). Thirty-eight patients (39 {\%}) underwent mastectomy. We found a statistically significant correlation between new foci in MRI and high Ki67 ≥ 25 {\%} (p <0.005). No other statistically significant correlation was established. Conclusion: MRI detected additional disease in 39 {\%} cases, requiring an additional biopsy 20 {\%}. Tumors with high proliferative index were significantly correlated with the detection of new foci in MRI.",
keywords = "Additional biopsies in breast cancer, Breast cancer, Breast MRI, Mastectomy",
author = "I. Calvo-Plaza and L. Ugidos and C. Mir{\'o} and P. Quevedo and M. Parras and C. M{\'a}rquez and {De La Cruz}, {J. J.} and A. Su{\'a}rez-Gauthier and P{\'e}rez, {F. J.} and M. Herrero and M. Marcos and M. Garc{\'i}a-Aranda and M. Hidalgo and Est{\'e}vez, {L. G.}",
year = "2013",
doi = "10.1007/s12094-012-0899-7",
language = "English (US)",
volume = "15",
pages = "205--210",
journal = "Clinical and Translational Oncology",
issn = "1699-048X",
publisher = "Springer-Verlag Italia",
number = "3",

}

TY - JOUR

T1 - Retrospective study assessing the role of MRI in the diagnostic procedures for early breast carcinoma

T2 - A correlation of new foci in the MRI with tumor pathological features

AU - Calvo-Plaza, I.

AU - Ugidos, L.

AU - Miró, C.

AU - Quevedo, P.

AU - Parras, M.

AU - Márquez, C.

AU - De La Cruz, J. J.

AU - Suárez-Gauthier, A.

AU - Pérez, F. J.

AU - Herrero, M.

AU - Marcos, M.

AU - García-Aranda, M.

AU - Hidalgo, M.

AU - Estévez, L. G.

PY - 2013

Y1 - 2013

N2 - Background: Use of breast magnetic resonance imaging (MRI) to detect breast cancer has generated significant debate. We analyze the role of breast MRI in the detection of additional disease and the need to perform additional biopsies in early breast carcinoma patients. In addition, we correlate the detection of new foci with tumor pathological features. Methods: Early breast carcinoma patients that had undergone an MRI as well as a mammography as diagnostic procedures were included in the study. The following pathologic features were studied: carcinoma type, histological grade, estrogen receptors (ER), progesterone receptors (PR), HER2 and Ki67. Univariate analysis was conducted to ascertain significant correlation among detection of new foci and each of the tumor pathological features. Results: Data from 98 patients have been analyzed: median age 49 years (range 35-79); carcinoma type: (a) infiltrative ductal carcinoma (n = 73, 74 %), (b) infiltrative lobular cancer (n = 12, 12 %), (c) ductal carcinoma in situ (n = 6, 6 %); amplified HER2 (n = 18, 18 %); grade III (n = 33, 33 %); Ki67 ≥ 25 % (n = 33, 33.67 %); positive ER and PR (n = 79, 80 %); triple negative tumors (n = 8, 8 %). MRI detected additional disease in 38 cases (39.58 %), and 20 led to an additional biopsy (20.4 %). Thirty-eight patients (39 %) underwent mastectomy. We found a statistically significant correlation between new foci in MRI and high Ki67 ≥ 25 % (p <0.005). No other statistically significant correlation was established. Conclusion: MRI detected additional disease in 39 % cases, requiring an additional biopsy 20 %. Tumors with high proliferative index were significantly correlated with the detection of new foci in MRI.

AB - Background: Use of breast magnetic resonance imaging (MRI) to detect breast cancer has generated significant debate. We analyze the role of breast MRI in the detection of additional disease and the need to perform additional biopsies in early breast carcinoma patients. In addition, we correlate the detection of new foci with tumor pathological features. Methods: Early breast carcinoma patients that had undergone an MRI as well as a mammography as diagnostic procedures were included in the study. The following pathologic features were studied: carcinoma type, histological grade, estrogen receptors (ER), progesterone receptors (PR), HER2 and Ki67. Univariate analysis was conducted to ascertain significant correlation among detection of new foci and each of the tumor pathological features. Results: Data from 98 patients have been analyzed: median age 49 years (range 35-79); carcinoma type: (a) infiltrative ductal carcinoma (n = 73, 74 %), (b) infiltrative lobular cancer (n = 12, 12 %), (c) ductal carcinoma in situ (n = 6, 6 %); amplified HER2 (n = 18, 18 %); grade III (n = 33, 33 %); Ki67 ≥ 25 % (n = 33, 33.67 %); positive ER and PR (n = 79, 80 %); triple negative tumors (n = 8, 8 %). MRI detected additional disease in 38 cases (39.58 %), and 20 led to an additional biopsy (20.4 %). Thirty-eight patients (39 %) underwent mastectomy. We found a statistically significant correlation between new foci in MRI and high Ki67 ≥ 25 % (p <0.005). No other statistically significant correlation was established. Conclusion: MRI detected additional disease in 39 % cases, requiring an additional biopsy 20 %. Tumors with high proliferative index were significantly correlated with the detection of new foci in MRI.

KW - Additional biopsies in breast cancer

KW - Breast cancer

KW - Breast MRI

KW - Mastectomy

UR - http://www.scopus.com/inward/record.url?scp=84878601841&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878601841&partnerID=8YFLogxK

U2 - 10.1007/s12094-012-0899-7

DO - 10.1007/s12094-012-0899-7

M3 - Article

VL - 15

SP - 205

EP - 210

JO - Clinical and Translational Oncology

JF - Clinical and Translational Oncology

SN - 1699-048X

IS - 3

ER -