Retrograde signaling by the neurotrophins follows a well-worn trk

Philip A. Barker, Natasha K. Hussain, Peter S. McPherson

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations


The mechanism that allows a neuron to send cues received at its terminal to its cell body and nucleus has proved elusive. However, a recent study by Howe and colleagues indicates that neurotrophin signaling via the trkA receptor requires formation of a signaling endosome containing NGF and trkA. Thus, endocytosis of the neurotrophin-receptor complex is a crucial step in the generation of intracellular signaling platforms required for activation and compartmentalization of signaling events.

Original languageEnglish (US)
Pages (from-to)379-381
Number of pages3
JournalTrends in neurosciences
Issue number8
StatePublished - Aug 1 2002

ASJC Scopus subject areas

  • Neuroscience(all)


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