Retreatment of full-thickness macular holes persisting after prior vitrectomy: A pilot study

D. Ie, B. M. Glaser, J. T. Thompson, R. N. Sjaarda, L. W. Gordon

Research output: Contribution to journalArticle

Abstract

Purpose: Vitrectomy with fluid-gas exchange has been shown to close more than one half of full-thickness macular holes, with improvement in visual acuity. By adding the appropriate dose of transforming growth factor-beta 2, a higher success rate has been reported. However, there still remain cases of macular holes that fail to close after vitreous surgery. The current pilot study is designed to determine whether reoperation may have a role in the management of cases that fail after vitreous surgery. Methods: Twelve eyes with persistent full-thickness macular holes that failed to close after an initial vitrectomy underwent reoperation using 1330 ng transforming growth factor-beta 2. Results: After the second operation, closure occurred in 12 (100%) of 12 eyes. Follow-up ranged from 8 to 16 months. Visual acuity also improved by two or more lines in 5 (42%) of 12 patients. Increased nuclear sclerosis occurred in nine (90%) of the ten phakic eyes. Of the five eyes showing visual improvement, four required cataract extraction and intraocular lens implantation. Conclusion: Retreatment of persistent full-thickness macular holes with transforming growth factor-beta 2 appears to have a beneficial effect on both neurosensory retinal flattening and visual outcome.

Original languageEnglish (US)
Pages (from-to)1787-1793
Number of pages7
JournalOphthalmology
Volume100
Issue number12
StatePublished - 1993
Externally publishedYes

Fingerprint

Retinal Perforations
Retreatment
Vitrectomy
Transforming Growth Factor beta
Reoperation
Visual Acuity
Intraocular Lens Implantation
Cataract Extraction
Case Management
Sclerosis
Gases

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ie, D., Glaser, B. M., Thompson, J. T., Sjaarda, R. N., & Gordon, L. W. (1993). Retreatment of full-thickness macular holes persisting after prior vitrectomy: A pilot study. Ophthalmology, 100(12), 1787-1793.

Retreatment of full-thickness macular holes persisting after prior vitrectomy : A pilot study. / Ie, D.; Glaser, B. M.; Thompson, J. T.; Sjaarda, R. N.; Gordon, L. W.

In: Ophthalmology, Vol. 100, No. 12, 1993, p. 1787-1793.

Research output: Contribution to journalArticle

Ie, D, Glaser, BM, Thompson, JT, Sjaarda, RN & Gordon, LW 1993, 'Retreatment of full-thickness macular holes persisting after prior vitrectomy: A pilot study', Ophthalmology, vol. 100, no. 12, pp. 1787-1793.
Ie D, Glaser BM, Thompson JT, Sjaarda RN, Gordon LW. Retreatment of full-thickness macular holes persisting after prior vitrectomy: A pilot study. Ophthalmology. 1993;100(12):1787-1793.
Ie, D. ; Glaser, B. M. ; Thompson, J. T. ; Sjaarda, R. N. ; Gordon, L. W. / Retreatment of full-thickness macular holes persisting after prior vitrectomy : A pilot study. In: Ophthalmology. 1993 ; Vol. 100, No. 12. pp. 1787-1793.
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