Retinopathy in hemoglobin C trait (AC hemoglobinopathy)

Miltos Moschandreou, Spiros Galinos, Raul Valenzuela, Alexander A. Constantaras, Morton F. Goldberg, Junius Adams

Research output: Contribution to journalArticlepeer-review


Three patients (four eyes) with hemoglobin C trait (AC hemoglobinopathy) underwent hematologic, ophthalmoscopic, and fluorescein angiographic study. This is the first report of the resemblance of AC retinopathy to sickle cell retinopathy, especially the proliferative type. The structural analysis of hemoglobin C in the reported cases excluded the existence of sickling properties and rendered no satisfactory explanation for the pathogenesis of the retinopathy. The similarity of the proliferative retinopathy in hemoglobin C disease, sickle cell thalassemia, and hemoglobin C trait suggests a closely related pathogenesis.

Original languageEnglish (US)
Pages (from-to)465-471
Number of pages7
JournalAmerican journal of ophthalmology
Issue number4
StatePublished - Apr 1974
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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