TY - JOUR
T1 - Retinopathy in hemoglobin C trait (AC hemoglobinopathy)
AU - Moschandreou, Miltos
AU - Galinos, Spiros
AU - Valenzuela, Raul
AU - Constantaras, Alexander A.
AU - Goldberg, Morton F.
AU - Adams, Junius
N1 - Funding Information:
From the Department of Ophthalmology, Cook-County Hospital (Drs. Moschandrcou and Constantaras), and the Sickle Cell Eye Clinic, University of Illinois Eye and Ear Infirmary (Drs. Ga-linos, Goldberg, and Adams), Chicago, Illinois; and the Department of Ophthalmology, Baylor College of Medicine (Dr. Valenzuela), Houston, Texas. This study was supported in part by Public Health Service contract 72-2956B and grant 15168-01 from the National Heart and Lung Institute. Reprint requests to Morton F. Goldberg, M.D., University of Illinois Eve and Ear Infirmary, 1855 W. Taylor St., Chicago^ IL 60612.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1974/4
Y1 - 1974/4
N2 - Three patients (four eyes) with hemoglobin C trait (AC hemoglobinopathy) underwent hematologic, ophthalmoscopic, and fluorescein angiographic study. This is the first report of the resemblance of AC retinopathy to sickle cell retinopathy, especially the proliferative type. The structural analysis of hemoglobin C in the reported cases excluded the existence of sickling properties and rendered no satisfactory explanation for the pathogenesis of the retinopathy. The similarity of the proliferative retinopathy in hemoglobin C disease, sickle cell thalassemia, and hemoglobin C trait suggests a closely related pathogenesis.
AB - Three patients (four eyes) with hemoglobin C trait (AC hemoglobinopathy) underwent hematologic, ophthalmoscopic, and fluorescein angiographic study. This is the first report of the resemblance of AC retinopathy to sickle cell retinopathy, especially the proliferative type. The structural analysis of hemoglobin C in the reported cases excluded the existence of sickling properties and rendered no satisfactory explanation for the pathogenesis of the retinopathy. The similarity of the proliferative retinopathy in hemoglobin C disease, sickle cell thalassemia, and hemoglobin C trait suggests a closely related pathogenesis.
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U2 - 10.1016/0002-9394(74)90456-5
DO - 10.1016/0002-9394(74)90456-5
M3 - Article
C2 - 4819450
AN - SCOPUS:0016160338
SN - 0002-9394
VL - 77
SP - 465
EP - 471
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 4
ER -