@article{7ea0a5198b7a4d8cae8682197e81c97c,
title = "Retinoid receptor signaling in postmitotic motor neurons regulates rostrocaudal positional identity and axonal projection pattern",
abstract = "The identity of motor neurons diverges markedly at different rostrocaudal levels of the spinal cord, but the signals that specify their fate remain poorly defined. We show that retinoid receptor activation in newly generated spinal motor neurons has a crucial role in specifying motor neuron columnar subtypes. Blockade of retinoid receptor signaling in brachial motor neurons inhibits lateral motor column differentiation and converts many of these neurons to thoracic columnar subtypes. Conversely, expression of a constitutively active retinoid receptor derivative impairs the differentiation of thoracic motor neuron columnar subtypes. These findings provide evidence for a regionally restricted role for retinoid signaling in the postmitotic specification of motor neuron columnar identity.",
author = "Shanthini Sockanathan and Thomas Perlmann and Jessell, {Thomas M.}",
note = "Funding Information: We thank Frankie Lo for expert technical assistance, Artur Kania for helpful advice on retrograde motor neuron labeling, Chris William for tips on in ovo electroporation, and Ira Schieren and Kathy MacArthur for help in preparing the manuscript. We are grateful to Jeremy Dasen, Joriene de Nooij, Alex Kolodkin, Ed Laufer, Ben Novitch, and Hynek Wichterle for comments on the manuscript. This work was supported by grants from the Muscular Dystrophy Association, the Whitehall Foundation, and NINDS to S.S., grants from the Swedish Foundation for Strategic Research to T.P., and a grant from NINDS to T.M.J. T.M.J. is also an Investigator of the Howard Hughes Medical Institute.",
year = "2003",
month = sep,
day = "25",
doi = "10.1016/S0896-6273(03)00532-4",
language = "English (US)",
volume = "40",
pages = "97--111",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "1",
}