Abstract
Retinoic acid-dependent homeobox Hoxb-1 gene expression offers an unanticipated example of both a positive and a negative transcriptional activity of RA, as exerted at different times during embryogenesis. A paradigm for the transduction of positive and negative signaling is the discovery that retinoic acid response elements (RAREs), positioned in the 3' enhancer and 5' promoter of the Hoxb-1 gene, may function respectively as positive and negative regulators, thereby permitting a diffused (early positive) as well as a segmentally specified and limited (late negative) expression of the gene. This molecular action of retinoic acid may provide a mechanism for our understanding of normal embryogenesis and of the interference with this process by ectopic retinoic acid, thereby leading to teratogenesis.
Original language | English (US) |
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Pages (from-to) | 61-63 |
Number of pages | 3 |
Journal | Nutrition reviews |
Volume | 54 |
Issue number | 2 I |
DOIs | |
State | Published - Feb 1996 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics