Retinoic acid response elements as positive and negative regulators of the expression of the homeobox b-1 gene

Luigi M. De Luca, Sharon A. Ross

Research output: Contribution to journalShort survey

Abstract

Retinoic acid-dependent homeobox Hoxb-1 gene expression offers an unanticipated example of both a positive and a negative transcriptional activity of RA, as exerted at different times during embryogenesis. A paradigm for the transduction of positive and negative signaling is the discovery that retinoic acid response elements (RAREs), positioned in the 3' enhancer and 5' promoter of the Hoxb-1 gene, may function respectively as positive and negative regulators, thereby permitting a diffused (early positive) as well as a segmentally specified and limited (late negative) expression of the gene. This molecular action of retinoic acid may provide a mechanism for our understanding of normal embryogenesis and of the interference with this process by ectopic retinoic acid, thereby leading to teratogenesis.

Original languageEnglish (US)
Pages (from-to)61-63
Number of pages3
JournalNutrition reviews
Volume54
Issue number2 I
DOIs
StatePublished - Feb 1996

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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