Retinoic acid-induced duplication of the zebrafish retina

George A. Hyatt; Ellen A. Schmitt; Nicholas R. Marsh-Armstrong; John E. Dowling

doi:10.1073/pnas.89.17.8293

Retinoic acid-induced duplication of the zebrafish retina

George A. Hyatt, Ellen A. Schmitt, Nicholas R. Marsh-Armstrong, John E. Dowling

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88 Scopus citations

Abstract

Exogenous treatment of zebrafish embryos with retinoic acid induces a duplication of the retinas during development. These effects occur only when retinoic acid is applied within a 2-hr period prior to and during the initial formation of the optic primordia, and they are concentration-dependent. Light microscopic examination reveals that the second retina derives from cells in the ventral region of the developing eyecup that normally become pigment epithelial cells. Two distinct ganglion cell fields are usually observed in eyes with duplicated retinas. Bundles of axons from each ganglion cell field join as they leave the eye and innervate the contralateral tectum.

Original language	English (US)
Pages (from-to)	8293-8297
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	89
Issue number	17
DOIs	https://doi.org/10.1073/pnas.89.17.8293
State	Published - 1992
Externally published	Yes

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title = "Retinoic acid-induced duplication of the zebrafish retina",

abstract = "Exogenous treatment of zebrafish embryos with retinoic acid induces a duplication of the retinas during development. These effects occur only when retinoic acid is applied within a 2-hr period prior to and during the initial formation of the optic primordia, and they are concentration-dependent. Light microscopic examination reveals that the second retina derives from cells in the ventral region of the developing eyecup that normally become pigment epithelial cells. Two distinct ganglion cell fields are usually observed in eyes with duplicated retinas. Bundles of axons from each ganglion cell field join as they leave the eye and innervate the contralateral tectum.",

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AU - Schmitt, Ellen A.

AU - Marsh-Armstrong, Nicholas R.

AU - Dowling, John E.

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Y1 - 1992

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AB - Exogenous treatment of zebrafish embryos with retinoic acid induces a duplication of the retinas during development. These effects occur only when retinoic acid is applied within a 2-hr period prior to and during the initial formation of the optic primordia, and they are concentration-dependent. Light microscopic examination reveals that the second retina derives from cells in the ventral region of the developing eyecup that normally become pigment epithelial cells. Two distinct ganglion cell fields are usually observed in eyes with duplicated retinas. Bundles of axons from each ganglion cell field join as they leave the eye and innervate the contralateral tectum.

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Retinoic acid-induced duplication of the zebrafish retina

Abstract

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