Retinoic acid binding protein in normal and neoplastic rat prostate

M. S. Gesell, M. J. Brandes, E. A. Arnold, John Tod Isaacs, H. Ueda, J. C. Millan

Research output: Contribution to journalArticle

Abstract

Sucrose density gradient analysis of cytosol from normal and neoplastic rat prostatic tissues exhibited a peak of (3H) retinoic acid binding in the 2S region, corresponding to the cytoplasmic retinoic acid binding protein (cRABP). In the Fisher-Copenhagen F1 rat, cRABP was present in the lateral lobe, but could not be detected in the ventral nor in the dorsal prostatic lobes. Four sublines of the R-3327 rat prostatic tumor contained similar levels of this binding protein. The absence of cRABP in the normal tissue of origin of the R-3327 tumor, the rat dorsal prostate, and reappearance in the neoplastic tissues follows a pattern described in other human and animal tumors. The occurrence of cRABP in the well-differentiated as well as in the anaplastic R-3327 tumors in which markers which reflect a state of differentiation and hormonal regulation, such as androgen receptor, 5α reductase, and secretory acid phosphatase are either markedly reduced or absent, points to cRABP as a marker of malignant transformation.

Original languageEnglish (US)
Pages (from-to)131-138
Number of pages8
JournalProstate
Volume3
Issue number2
DOIs
StatePublished - 1982

Fingerprint

Retinoic Acid Receptors
Prostate
Neoplasms
Androgen Receptors
Acid Phosphatase
Tretinoin
Cytosol
Sucrose
Carrier Proteins
Oxidoreductases

ASJC Scopus subject areas

  • Urology

Cite this

Gesell, M. S., Brandes, M. J., Arnold, E. A., Isaacs, J. T., Ueda, H., & Millan, J. C. (1982). Retinoic acid binding protein in normal and neoplastic rat prostate. Prostate, 3(2), 131-138. https://doi.org/10.1002/pros.2990030205

Retinoic acid binding protein in normal and neoplastic rat prostate. / Gesell, M. S.; Brandes, M. J.; Arnold, E. A.; Isaacs, John Tod; Ueda, H.; Millan, J. C.

In: Prostate, Vol. 3, No. 2, 1982, p. 131-138.

Research output: Contribution to journalArticle

Gesell, MS, Brandes, MJ, Arnold, EA, Isaacs, JT, Ueda, H & Millan, JC 1982, 'Retinoic acid binding protein in normal and neoplastic rat prostate', Prostate, vol. 3, no. 2, pp. 131-138. https://doi.org/10.1002/pros.2990030205
Gesell, M. S. ; Brandes, M. J. ; Arnold, E. A. ; Isaacs, John Tod ; Ueda, H. ; Millan, J. C. / Retinoic acid binding protein in normal and neoplastic rat prostate. In: Prostate. 1982 ; Vol. 3, No. 2. pp. 131-138.
@article{f0128630e27b4298910d87b03d0adb98,
title = "Retinoic acid binding protein in normal and neoplastic rat prostate",
abstract = "Sucrose density gradient analysis of cytosol from normal and neoplastic rat prostatic tissues exhibited a peak of (3H) retinoic acid binding in the 2S region, corresponding to the cytoplasmic retinoic acid binding protein (cRABP). In the Fisher-Copenhagen F1 rat, cRABP was present in the lateral lobe, but could not be detected in the ventral nor in the dorsal prostatic lobes. Four sublines of the R-3327 rat prostatic tumor contained similar levels of this binding protein. The absence of cRABP in the normal tissue of origin of the R-3327 tumor, the rat dorsal prostate, and reappearance in the neoplastic tissues follows a pattern described in other human and animal tumors. The occurrence of cRABP in the well-differentiated as well as in the anaplastic R-3327 tumors in which markers which reflect a state of differentiation and hormonal regulation, such as androgen receptor, 5α reductase, and secretory acid phosphatase are either markedly reduced or absent, points to cRABP as a marker of malignant transformation.",
author = "Gesell, {M. S.} and Brandes, {M. J.} and Arnold, {E. A.} and Isaacs, {John Tod} and H. Ueda and Millan, {J. C.}",
year = "1982",
doi = "10.1002/pros.2990030205",
language = "English (US)",
volume = "3",
pages = "131--138",
journal = "Prostate",
issn = "0270-4137",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Retinoic acid binding protein in normal and neoplastic rat prostate

AU - Gesell, M. S.

AU - Brandes, M. J.

AU - Arnold, E. A.

AU - Isaacs, John Tod

AU - Ueda, H.

AU - Millan, J. C.

PY - 1982

Y1 - 1982

N2 - Sucrose density gradient analysis of cytosol from normal and neoplastic rat prostatic tissues exhibited a peak of (3H) retinoic acid binding in the 2S region, corresponding to the cytoplasmic retinoic acid binding protein (cRABP). In the Fisher-Copenhagen F1 rat, cRABP was present in the lateral lobe, but could not be detected in the ventral nor in the dorsal prostatic lobes. Four sublines of the R-3327 rat prostatic tumor contained similar levels of this binding protein. The absence of cRABP in the normal tissue of origin of the R-3327 tumor, the rat dorsal prostate, and reappearance in the neoplastic tissues follows a pattern described in other human and animal tumors. The occurrence of cRABP in the well-differentiated as well as in the anaplastic R-3327 tumors in which markers which reflect a state of differentiation and hormonal regulation, such as androgen receptor, 5α reductase, and secretory acid phosphatase are either markedly reduced or absent, points to cRABP as a marker of malignant transformation.

AB - Sucrose density gradient analysis of cytosol from normal and neoplastic rat prostatic tissues exhibited a peak of (3H) retinoic acid binding in the 2S region, corresponding to the cytoplasmic retinoic acid binding protein (cRABP). In the Fisher-Copenhagen F1 rat, cRABP was present in the lateral lobe, but could not be detected in the ventral nor in the dorsal prostatic lobes. Four sublines of the R-3327 rat prostatic tumor contained similar levels of this binding protein. The absence of cRABP in the normal tissue of origin of the R-3327 tumor, the rat dorsal prostate, and reappearance in the neoplastic tissues follows a pattern described in other human and animal tumors. The occurrence of cRABP in the well-differentiated as well as in the anaplastic R-3327 tumors in which markers which reflect a state of differentiation and hormonal regulation, such as androgen receptor, 5α reductase, and secretory acid phosphatase are either markedly reduced or absent, points to cRABP as a marker of malignant transformation.

UR - http://www.scopus.com/inward/record.url?scp=0020316124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020316124&partnerID=8YFLogxK

U2 - 10.1002/pros.2990030205

DO - 10.1002/pros.2990030205

M3 - Article

C2 - 6283503

AN - SCOPUS:0020316124

VL - 3

SP - 131

EP - 138

JO - Prostate

JF - Prostate

SN - 0270-4137

IS - 2

ER -