Retinitis pigmentosa: Immunohistochemical and biochemical studies of the retina

M. M. Rodrigues, B. Wiggert, M. O.M. T'so, G. J. Chader

Research output: Contribution to journalArticlepeer-review


Several immunohistochemical and biochemical characteristics of retinas from two patients with retinitis pigmentosa (RP) were examined. Histochemically, interphotoreceptor retinoid-binding protein (IRBP) was found in the interphotoreceptor space in small areas of preserved peripheral retina, although enzyme-linked immunosorbent assay suggested that little IRBP was present. Antibodies to glial fibrillary acidic protein and factor VIII-related antigen corroborated retinal gliosis and retinal vessel attenuation, respectively, in the RP cases. Fibronectin showed similar staining in normal and affected tissue.

Original languageEnglish (US)
Pages (from-to)79-83
Number of pages5
JournalCanadian Journal of Ophthalmology
Issue number3
StatePublished - Jan 1 1986
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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