Retinitis pigmentosa: Immunohistochemical and biochemical studies of the retina

M. M. Rodrigues; B. Wiggert; M. O.M. T'so; G. J. Chader

Retinitis pigmentosa: Immunohistochemical and biochemical studies of the retina

M. M. Rodrigues, B. Wiggert, M. O.M. T'so, G. J. Chader

Research output: Contribution to journal › Article › peer-review

Abstract

Several immunohistochemical and biochemical characteristics of retinas from two patients with retinitis pigmentosa (RP) were examined. Histochemically, interphotoreceptor retinoid-binding protein (IRBP) was found in the interphotoreceptor space in small areas of preserved peripheral retina, although enzyme-linked immunosorbent assay suggested that little IRBP was present. Antibodies to glial fibrillary acidic protein and factor VIII-related antigen corroborated retinal gliosis and retinal vessel attenuation, respectively, in the RP cases. Fibronectin showed similar staining in normal and affected tissue.

Original language	English (US)
Pages (from-to)	79-83
Number of pages	5
Journal	Canadian Journal of Ophthalmology
Volume	21
Issue number	3
State	Published - Jan 1 1986
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

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abstract = "Several immunohistochemical and biochemical characteristics of retinas from two patients with retinitis pigmentosa (RP) were examined. Histochemically, interphotoreceptor retinoid-binding protein (IRBP) was found in the interphotoreceptor space in small areas of preserved peripheral retina, although enzyme-linked immunosorbent assay suggested that little IRBP was present. Antibodies to glial fibrillary acidic protein and factor VIII-related antigen corroborated retinal gliosis and retinal vessel attenuation, respectively, in the RP cases. Fibronectin showed similar staining in normal and affected tissue.",

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AU - Chader, G. J.

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AB - Several immunohistochemical and biochemical characteristics of retinas from two patients with retinitis pigmentosa (RP) were examined. Histochemically, interphotoreceptor retinoid-binding protein (IRBP) was found in the interphotoreceptor space in small areas of preserved peripheral retina, although enzyme-linked immunosorbent assay suggested that little IRBP was present. Antibodies to glial fibrillary acidic protein and factor VIII-related antigen corroborated retinal gliosis and retinal vessel attenuation, respectively, in the RP cases. Fibronectin showed similar staining in normal and affected tissue.

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