Retinal vascular changes and right ventricular structure and function: the MESA-Right Ventricle and MESA-Eye studies

Anthony C. Chyou, Barbara E.K. Klein, Ronald Klein, R. Graham Barr, Mary Frances Cotch, Amy Praestgaard, Tien Y. Wong, Joao Lima, David A. Bluemke, Steven Kawut

Research output: Contribution to journalArticle

Abstract

Retinal vessel diameters have been associated with left ventricular morphology and function but their relationship with the right ventricle (RV) has not been studied. We hypothesized that wider retinal venules and narrower retinal arterioles are associated with RV morphology and function. RV end-diastolic mass (RVEDM), end-diastolic volume (RVEDV), end-systolic volume (RVESV), stroke volume (RVSV), and ejection fraction (RVEF) were assessed using cardiac magnetic resonance imaging (MRI) scans of 4204 participants without clinical cardiovascular disease at the baseline examination; retinal photography was obtained at the second examination. Mean diameters of retinal arterioles and venules were measured and summarized as central retinal vein and artery equivalents (“veins” and “arteries,” respectively). After adjusting for covariates, wider veins were associated with greater RVEDM and RVEDV in women (P = 0.04 and P = 0.02, respectively), whereas there was an inverse association with RVEDV in men (P = 0.02). In both sexes, narrower arteries were associated with lower RVEDM (P < 0.001 in women and P = 0.002 in men) and smaller RVEDV (P < 0.001 in women and P = 0.04 in men) in adjusted models. Narrower arteries were also associated with lower RVEF in men but this was of borderline significance after adjusting for the LVEF (P = 0.08). Wider retinal venular diameter was associated with sex-specific changes in RVEDM and RVEDV in adults without clinical cardiovascular disease. Narrower retinal arteriolar diameter was associated with significantly lower RVEDM and smaller RVEDV in both sexes.

Original languageEnglish (US)
JournalPulmonary Circulation
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2019

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Right Ventricular Function
Retinal Vessels
Heart Ventricles
Venules
Arteries
Arterioles
Veins
Cardiovascular Diseases
Retinal Artery
Retinal Vein
Photography
Left Ventricular Function
Stroke Volume
Magnetic Resonance Imaging

Keywords

  • pulmonary hypertension
  • retinal vasculature
  • right ventricle

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Chyou, A. C., Klein, B. E. K., Klein, R., Barr, R. G., Cotch, M. F., Praestgaard, A., ... Kawut, S. (2019). Retinal vascular changes and right ventricular structure and function: the MESA-Right Ventricle and MESA-Eye studies. Pulmonary Circulation, 9(1). https://doi.org/10.1177/2045894018819781

Retinal vascular changes and right ventricular structure and function : the MESA-Right Ventricle and MESA-Eye studies. / Chyou, Anthony C.; Klein, Barbara E.K.; Klein, Ronald; Barr, R. Graham; Cotch, Mary Frances; Praestgaard, Amy; Wong, Tien Y.; Lima, Joao; Bluemke, David A.; Kawut, Steven.

In: Pulmonary Circulation, Vol. 9, No. 1, 01.01.2019.

Research output: Contribution to journalArticle

Chyou, AC, Klein, BEK, Klein, R, Barr, RG, Cotch, MF, Praestgaard, A, Wong, TY, Lima, J, Bluemke, DA & Kawut, S 2019, 'Retinal vascular changes and right ventricular structure and function: the MESA-Right Ventricle and MESA-Eye studies', Pulmonary Circulation, vol. 9, no. 1. https://doi.org/10.1177/2045894018819781
Chyou, Anthony C. ; Klein, Barbara E.K. ; Klein, Ronald ; Barr, R. Graham ; Cotch, Mary Frances ; Praestgaard, Amy ; Wong, Tien Y. ; Lima, Joao ; Bluemke, David A. ; Kawut, Steven. / Retinal vascular changes and right ventricular structure and function : the MESA-Right Ventricle and MESA-Eye studies. In: Pulmonary Circulation. 2019 ; Vol. 9, No. 1.
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