Retinal Thickness on Stratus Optical Coherence Tomography in People with Diabetes and Minimal or No Diabetic Retinopathy

Neil M. Bressler; Allison R. Edwards; Andrew N. Antoszyk; Roy W. Beck; David J. Browning; Antonio P. Ciardella; Ronald P. Danis; Michael J. Elman; Scott M. Friedman; Adam R. Glassman; Jeffrey G. Gross; Helen K. Li; Timothy J. Murtha; Thomas W. Stone; Jennifer K. Sun

doi:10.1016/j.ajo.2007.12.025

Retinal Thickness on Stratus Optical Coherence Tomography in People with Diabetes and Minimal or No Diabetic Retinopathy

Neil M. Bressler, Allison R. Edwards, Andrew N. Antoszyk, Roy W. Beck, David J. Browning, Antonio P. Ciardella, Ronald P. Danis, Michael J. Elman, Scott M. Friedman, Adam R. Glassman, Jeffrey G. Gross, Helen K. Li, Timothy J. Murtha, Thomas W. Stone, Jennifer K. Sun

School of Medicine

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

Purpose: To evaluate optical coherence tomography (OCT) thickness of the macula in people with diabetes but minimal or no retinopathy and to compare these findings with published normative data in the literature from subjects reported to have no retinal disease. Design: Cross-sectional study. Methods: In a multicenter community- and university-based practices setting, 97 subjects with diabetes with no or minimal diabetic retinopathy and no central retinal thickening on clinical examination and a center point thickness of 225 μm or less on OCT (Stratus OCT; Carl Zeiss Meditec, Dublin, California, USA) were recruited. Electronic Early Treatment of Diabetic Retinopathy Study best-corrected visual acuity, seven-field stereoscopic color fundus photographs, and Stratus OCT fast macular scan were noted. Main outcome measures were central subfield (CSF) thickness measured on Stratus OCT. Results: On average, CSF thickness was 201 ± 22 μm. CSF thickness was significantly greater in retinas from men than retinas from women (mean ± standard deviation, 209 ± 18 μm vs 194 ± 23 μm; P < .001). After adjusting for gender, no additional factors were found to be associated significantly with CSF thickness (P > .10). Conclusions: CSF thicknesses on Stratus OCT in people with diabetes and minimal or no retinopathy are similar to thicknesses reported from a normative database of people without diabetes. CSF thickness is greater in men than in women, consistent with many, but not all, previous reports. Studies involving comparisons of retinal thickness with expected norms should consider different mean values for women and men.

Original language	English (US)
Pages (from-to)	894-901.e1
Journal	American journal of ophthalmology
Volume	145
Issue number	5
DOIs	https://doi.org/10.1016/j.ajo.2007.12.025
State	Published - May 2008

ASJC Scopus subject areas

Ophthalmology

Access to Document

10.1016/j.ajo.2007.12.025

Cite this

Bressler, N. M., Edwards, A. R., Antoszyk, A. N., Beck, R. W., Browning, D. J., Ciardella, A. P., Danis, R. P., Elman, M. J., Friedman, S. M., Glassman, A. R., Gross, J. G., Li, H. K., Murtha, T. J., Stone, T. W., & Sun, J. K. (2008). Retinal Thickness on Stratus Optical Coherence Tomography in People with Diabetes and Minimal or No Diabetic Retinopathy. American journal of ophthalmology, 145(5), 894-901.e1. https://doi.org/10.1016/j.ajo.2007.12.025

Bressler, NM, Edwards, AR, Antoszyk, AN, Beck, RW, Browning, DJ, Ciardella, AP, Danis, RP, Elman, MJ, Friedman, SM, Glassman, AR, Gross, JG, Li, HK, Murtha, TJ, Stone, TW & Sun, JK 2008, 'Retinal Thickness on Stratus Optical Coherence Tomography in People with Diabetes and Minimal or No Diabetic Retinopathy', American journal of ophthalmology, vol. 145, no. 5, pp. 894-901.e1. https://doi.org/10.1016/j.ajo.2007.12.025

@article{60620edffb1648b0aca46b2b6612e4bc,

title = "Retinal Thickness on Stratus Optical Coherence Tomography in People with Diabetes and Minimal or No Diabetic Retinopathy",

abstract = "Purpose: To evaluate optical coherence tomography (OCT) thickness of the macula in people with diabetes but minimal or no retinopathy and to compare these findings with published normative data in the literature from subjects reported to have no retinal disease. Design: Cross-sectional study. Methods: In a multicenter community- and university-based practices setting, 97 subjects with diabetes with no or minimal diabetic retinopathy and no central retinal thickening on clinical examination and a center point thickness of 225 μm or less on OCT (Stratus OCT; Carl Zeiss Meditec, Dublin, California, USA) were recruited. Electronic Early Treatment of Diabetic Retinopathy Study best-corrected visual acuity, seven-field stereoscopic color fundus photographs, and Stratus OCT fast macular scan were noted. Main outcome measures were central subfield (CSF) thickness measured on Stratus OCT. Results: On average, CSF thickness was 201 ± 22 μm. CSF thickness was significantly greater in retinas from men than retinas from women (mean ± standard deviation, 209 ± 18 μm vs 194 ± 23 μm; P < .001). After adjusting for gender, no additional factors were found to be associated significantly with CSF thickness (P > .10). Conclusions: CSF thicknesses on Stratus OCT in people with diabetes and minimal or no retinopathy are similar to thicknesses reported from a normative database of people without diabetes. CSF thickness is greater in men than in women, consistent with many, but not all, previous reports. Studies involving comparisons of retinal thickness with expected norms should consider different mean values for women and men.",

author = "Bressler, {Neil M.} and Edwards, {Allison R.} and Antoszyk, {Andrew N.} and Beck, {Roy W.} and Browning, {David J.} and Ciardella, {Antonio P.} and Danis, {Ronald P.} and Elman, {Michael J.} and Friedman, {Scott M.} and Glassman, {Adam R.} and Gross, {Jeffrey G.} and Li, {Helen K.} and Murtha, {Timothy J.} and Stone, {Thomas W.} and Sun, {Jennifer K.}",

note = "Funding Information: This study was supported through a cooperative agreement from the National Eye Institute, Bethesda, Maryland and the National Institute of Diabetes and Digestive and Kidney Diseases Grants EY14231, EY14269, and EY14229, Bethesda, Maryland. A listing of financial disclosures for all authors is available as Supplemental Material at AJO.com. Involved in design of study (R.B., N.B., D.B., A.C., M.E., A.G., T.S.). All of the authors were involved in collection, management, analysis, or interpretation of the data and preparation, review, or approval of the manuscript. The protocol and Health Insurance Portability and Accountability Act-compliant informed consent forms were approved by multiple institutional review boards. ",

year = "2008",

month = may,

doi = "10.1016/j.ajo.2007.12.025",

language = "English (US)",

volume = "145",

pages = "894--901.e1",

journal = "American journal of ophthalmology",

issn = "0002-9394",

publisher = "Elsevier USA",

number = "5",

}

TY - JOUR

T1 - Retinal Thickness on Stratus Optical Coherence Tomography in People with Diabetes and Minimal or No Diabetic Retinopathy

AU - Bressler, Neil M.

AU - Edwards, Allison R.

AU - Antoszyk, Andrew N.

AU - Beck, Roy W.

AU - Browning, David J.

AU - Ciardella, Antonio P.

AU - Danis, Ronald P.

AU - Elman, Michael J.

AU - Friedman, Scott M.

AU - Glassman, Adam R.

AU - Gross, Jeffrey G.

AU - Li, Helen K.

AU - Murtha, Timothy J.

AU - Stone, Thomas W.

AU - Sun, Jennifer K.

N1 - Funding Information: This study was supported through a cooperative agreement from the National Eye Institute, Bethesda, Maryland and the National Institute of Diabetes and Digestive and Kidney Diseases Grants EY14231, EY14269, and EY14229, Bethesda, Maryland. A listing of financial disclosures for all authors is available as Supplemental Material at AJO.com. Involved in design of study (R.B., N.B., D.B., A.C., M.E., A.G., T.S.). All of the authors were involved in collection, management, analysis, or interpretation of the data and preparation, review, or approval of the manuscript. The protocol and Health Insurance Portability and Accountability Act-compliant informed consent forms were approved by multiple institutional review boards.

PY - 2008/5

Y1 - 2008/5

N2 - Purpose: To evaluate optical coherence tomography (OCT) thickness of the macula in people with diabetes but minimal or no retinopathy and to compare these findings with published normative data in the literature from subjects reported to have no retinal disease. Design: Cross-sectional study. Methods: In a multicenter community- and university-based practices setting, 97 subjects with diabetes with no or minimal diabetic retinopathy and no central retinal thickening on clinical examination and a center point thickness of 225 μm or less on OCT (Stratus OCT; Carl Zeiss Meditec, Dublin, California, USA) were recruited. Electronic Early Treatment of Diabetic Retinopathy Study best-corrected visual acuity, seven-field stereoscopic color fundus photographs, and Stratus OCT fast macular scan were noted. Main outcome measures were central subfield (CSF) thickness measured on Stratus OCT. Results: On average, CSF thickness was 201 ± 22 μm. CSF thickness was significantly greater in retinas from men than retinas from women (mean ± standard deviation, 209 ± 18 μm vs 194 ± 23 μm; P < .001). After adjusting for gender, no additional factors were found to be associated significantly with CSF thickness (P > .10). Conclusions: CSF thicknesses on Stratus OCT in people with diabetes and minimal or no retinopathy are similar to thicknesses reported from a normative database of people without diabetes. CSF thickness is greater in men than in women, consistent with many, but not all, previous reports. Studies involving comparisons of retinal thickness with expected norms should consider different mean values for women and men.

AB - Purpose: To evaluate optical coherence tomography (OCT) thickness of the macula in people with diabetes but minimal or no retinopathy and to compare these findings with published normative data in the literature from subjects reported to have no retinal disease. Design: Cross-sectional study. Methods: In a multicenter community- and university-based practices setting, 97 subjects with diabetes with no or minimal diabetic retinopathy and no central retinal thickening on clinical examination and a center point thickness of 225 μm or less on OCT (Stratus OCT; Carl Zeiss Meditec, Dublin, California, USA) were recruited. Electronic Early Treatment of Diabetic Retinopathy Study best-corrected visual acuity, seven-field stereoscopic color fundus photographs, and Stratus OCT fast macular scan were noted. Main outcome measures were central subfield (CSF) thickness measured on Stratus OCT. Results: On average, CSF thickness was 201 ± 22 μm. CSF thickness was significantly greater in retinas from men than retinas from women (mean ± standard deviation, 209 ± 18 μm vs 194 ± 23 μm; P < .001). After adjusting for gender, no additional factors were found to be associated significantly with CSF thickness (P > .10). Conclusions: CSF thicknesses on Stratus OCT in people with diabetes and minimal or no retinopathy are similar to thicknesses reported from a normative database of people without diabetes. CSF thickness is greater in men than in women, consistent with many, but not all, previous reports. Studies involving comparisons of retinal thickness with expected norms should consider different mean values for women and men.

UR - http://www.scopus.com/inward/record.url?scp=43049148976&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=43049148976&partnerID=8YFLogxK

U2 - 10.1016/j.ajo.2007.12.025

DO - 10.1016/j.ajo.2007.12.025

M3 - Article

C2 - 18294608

AN - SCOPUS:43049148976

SN - 0002-9394

VL - 145

SP - 894-901.e1

JO - American journal of ophthalmology

JF - American journal of ophthalmology

IS - 5

ER -

Retinal Thickness on Stratus Optical Coherence Tomography in People with Diabetes and Minimal or No Diabetic Retinopathy

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this