Retinal Thickness and Microvascular Changes in Children With Sickle Cell Disease Evaluated by Optical Coherence Tomography (OCT) and OCT Angiography

Sally S. Ong, Marguerite O. Linz, Ximin Li, T. Y.Alvin Liu, Ian C. Han, Adrienne W. Scott

Research output: Contribution to journalArticle

Abstract

Purpose: To compare the severity of macular vascular changes in children with sickle cell disease (SCD) vs age- and race-matched controls. Design: Cross-sectional study. Methods: Children (<18 years old) with HbSS and HbS variant (HbSC and HbS thalassemia) genotypes, and their age- and race-matched controls, were recruited between January 2017 and December 2018. All subjects underwent optical coherence tomography angiography (OCTA) scans centered on the fovea and temporal macula. Retinal thickness, superficial capillary plexus (SCP) and deep capillary plexus (DCP) vessel density (VD), and foveal avascular zone (FAZ) size were measured and compared between HbSS and HbS variant vs controls. Results: Thirty-four HbSS, 34 HbS variant (Goldberg staging 0-3 for SCD eyes), and 24 control eyes (total 48 children, aged 5-17 years) were included. Total VD (3-mm ETDRS circle) was lower in HbS variant eyes than in controls for both the SCP (42.9% vs 47.7%, P = .02) and DCP (47.4% vs 52.6%, P = .01). In HbSS eyes, VD was lower in the DCP (47.7%, P = .008) but not in the SCP (45.5%, P = .5), compared to controls. A higher proportion of HbSS (n = 18, 55%) than HbS variant eyes (n = 9, 26%) had pathologic areas of retinal thinning associated with SCP and DCP flow loss (P = .03). However, retinal thickness measurements and FAZ size did not differ between either HbSS or HbS variant group vs controls. Conclusions: Children with SCD have similar retinal thickness but less dense vasculature on OCTA compared to age and race-matched controls, suggesting that microvascular insult may precede structural thinning.

Original languageEnglish (US)
JournalAmerican journal of ophthalmology
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Optical Coherence Tomography
Sickle Cell Anemia
Angiography
Thalassemia
Blood Vessels
Cross-Sectional Studies
Genotype
Control Groups

ASJC Scopus subject areas

  • Ophthalmology

Cite this

@article{97bad8b120d94e7dbe67080e261250f0,
title = "Retinal Thickness and Microvascular Changes in Children With Sickle Cell Disease Evaluated by Optical Coherence Tomography (OCT) and OCT Angiography",
abstract = "Purpose: To compare the severity of macular vascular changes in children with sickle cell disease (SCD) vs age- and race-matched controls. Design: Cross-sectional study. Methods: Children (<18 years old) with HbSS and HbS variant (HbSC and HbS thalassemia) genotypes, and their age- and race-matched controls, were recruited between January 2017 and December 2018. All subjects underwent optical coherence tomography angiography (OCTA) scans centered on the fovea and temporal macula. Retinal thickness, superficial capillary plexus (SCP) and deep capillary plexus (DCP) vessel density (VD), and foveal avascular zone (FAZ) size were measured and compared between HbSS and HbS variant vs controls. Results: Thirty-four HbSS, 34 HbS variant (Goldberg staging 0-3 for SCD eyes), and 24 control eyes (total 48 children, aged 5-17 years) were included. Total VD (3-mm ETDRS circle) was lower in HbS variant eyes than in controls for both the SCP (42.9{\%} vs 47.7{\%}, P = .02) and DCP (47.4{\%} vs 52.6{\%}, P = .01). In HbSS eyes, VD was lower in the DCP (47.7{\%}, P = .008) but not in the SCP (45.5{\%}, P = .5), compared to controls. A higher proportion of HbSS (n = 18, 55{\%}) than HbS variant eyes (n = 9, 26{\%}) had pathologic areas of retinal thinning associated with SCP and DCP flow loss (P = .03). However, retinal thickness measurements and FAZ size did not differ between either HbSS or HbS variant group vs controls. Conclusions: Children with SCD have similar retinal thickness but less dense vasculature on OCTA compared to age and race-matched controls, suggesting that microvascular insult may precede structural thinning.",
author = "Ong, {Sally S.} and Linz, {Marguerite O.} and Ximin Li and Liu, {T. Y.Alvin} and Han, {Ian C.} and Scott, {Adrienne W.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.ajo.2019.08.019",
language = "English (US)",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",

}

TY - JOUR

T1 - Retinal Thickness and Microvascular Changes in Children With Sickle Cell Disease Evaluated by Optical Coherence Tomography (OCT) and OCT Angiography

AU - Ong, Sally S.

AU - Linz, Marguerite O.

AU - Li, Ximin

AU - Liu, T. Y.Alvin

AU - Han, Ian C.

AU - Scott, Adrienne W.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: To compare the severity of macular vascular changes in children with sickle cell disease (SCD) vs age- and race-matched controls. Design: Cross-sectional study. Methods: Children (<18 years old) with HbSS and HbS variant (HbSC and HbS thalassemia) genotypes, and their age- and race-matched controls, were recruited between January 2017 and December 2018. All subjects underwent optical coherence tomography angiography (OCTA) scans centered on the fovea and temporal macula. Retinal thickness, superficial capillary plexus (SCP) and deep capillary plexus (DCP) vessel density (VD), and foveal avascular zone (FAZ) size were measured and compared between HbSS and HbS variant vs controls. Results: Thirty-four HbSS, 34 HbS variant (Goldberg staging 0-3 for SCD eyes), and 24 control eyes (total 48 children, aged 5-17 years) were included. Total VD (3-mm ETDRS circle) was lower in HbS variant eyes than in controls for both the SCP (42.9% vs 47.7%, P = .02) and DCP (47.4% vs 52.6%, P = .01). In HbSS eyes, VD was lower in the DCP (47.7%, P = .008) but not in the SCP (45.5%, P = .5), compared to controls. A higher proportion of HbSS (n = 18, 55%) than HbS variant eyes (n = 9, 26%) had pathologic areas of retinal thinning associated with SCP and DCP flow loss (P = .03). However, retinal thickness measurements and FAZ size did not differ between either HbSS or HbS variant group vs controls. Conclusions: Children with SCD have similar retinal thickness but less dense vasculature on OCTA compared to age and race-matched controls, suggesting that microvascular insult may precede structural thinning.

AB - Purpose: To compare the severity of macular vascular changes in children with sickle cell disease (SCD) vs age- and race-matched controls. Design: Cross-sectional study. Methods: Children (<18 years old) with HbSS and HbS variant (HbSC and HbS thalassemia) genotypes, and their age- and race-matched controls, were recruited between January 2017 and December 2018. All subjects underwent optical coherence tomography angiography (OCTA) scans centered on the fovea and temporal macula. Retinal thickness, superficial capillary plexus (SCP) and deep capillary plexus (DCP) vessel density (VD), and foveal avascular zone (FAZ) size were measured and compared between HbSS and HbS variant vs controls. Results: Thirty-four HbSS, 34 HbS variant (Goldberg staging 0-3 for SCD eyes), and 24 control eyes (total 48 children, aged 5-17 years) were included. Total VD (3-mm ETDRS circle) was lower in HbS variant eyes than in controls for both the SCP (42.9% vs 47.7%, P = .02) and DCP (47.4% vs 52.6%, P = .01). In HbSS eyes, VD was lower in the DCP (47.7%, P = .008) but not in the SCP (45.5%, P = .5), compared to controls. A higher proportion of HbSS (n = 18, 55%) than HbS variant eyes (n = 9, 26%) had pathologic areas of retinal thinning associated with SCP and DCP flow loss (P = .03). However, retinal thickness measurements and FAZ size did not differ between either HbSS or HbS variant group vs controls. Conclusions: Children with SCD have similar retinal thickness but less dense vasculature on OCTA compared to age and race-matched controls, suggesting that microvascular insult may precede structural thinning.

UR - http://www.scopus.com/inward/record.url?scp=85074425261&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074425261&partnerID=8YFLogxK

U2 - 10.1016/j.ajo.2019.08.019

DO - 10.1016/j.ajo.2019.08.019

M3 - Article

C2 - 31473216

AN - SCOPUS:85074425261

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

ER -