TY - JOUR
T1 - Retinal Thickness Analysis by Race, Gender, and Age Using Stratus OCT
AU - Kashani, Amir H.
AU - Zimmer-Galler, Ingrid E.
AU - Shah, Syed Mahmood
AU - Dustin, Laurie
AU - Do, Diana V.
AU - Eliott, Dean
AU - Haller, Julia A.
AU - Nguyen, Quan Dong
N1 - Funding Information:
Dr Kashani was a recipient of the ARVO Travel Grant Award and Johns Hopkins Medical School Research Stipend. Dr Nguyen is a recipient of an NIH RO1 Award ( EY017577 ) and the Physician Scientist Award from Research to Prevent Blindness, New York, New York. Dr. Kashani's employer, the University of Southern California, receives research funding from Reichert, Inc. , Depew, New York, to support the conduct of an unrelated study. Dr. Zimmer-Galler's employer, the Johns Hopkins University, receives research funding from EyeTel Imaging, Inc. , Columbia, Maryland. Dr Do's employer, the Johns Hopkins University, receives research funding from Genentech , Regeneron , Novartis , and Zeiss , among others; and her spouse serves on the Scientific Advisory Board for Heidelberg Engineering, Inc. Dr Nguyen serves on the Scientific Advisory Board for Heidelberg Engineering, Inc. Dr Nguyen's employer, the Johns Hopkins University, receives research funding from Genentech , Regeneron , Novartis , and Zeiss , among others. Involved in study design (Q.D.N., S.M.S., A.H.K.); patient recruitment (A.H.K., I.Z.G., J.A.H., D.V.D., Q.D.N., D.E.); collection, analysis, and preparation of data tables, figures, and graphs (A.H.K., L.D.); and preparation and editing of manuscript (A.H.K., Q.D.N., D.V.D., D.E., J.A.H.). Johns Hopkins University IRB and University of Southern California IRB approved this study.
PY - 2010/3
Y1 - 2010/3
N2 - Purpose: To detect differences in retinal thickness among patients of different race, gender, and age using Stratus OCT. Design: Cross-sectional study. Methods: In a multicenter, university-based study, 126 patients with no history of ocular disease were enrolled (78 diabetics without retinopathy and 48 nondiabetics). Optical coherence tomography measurements were performed using Stratus OCT. Statistical comparisons of center point foveal thickness and mean foveal thickness were made using generalized estimating equations adjusting for diabetic status, race, age, and gender. Results: The study population consisted of 36% male subjects, 39% Caucasian, 33% African-American, and 28% Hispanic. Mean foveal thickness was 191.6 ± 2.7 μm and 194.5 ± 2.7 μm for diabetics and nondiabetics, respectively (P = .49). Mean foveal thickness in male subjects was significantly larger than in female (201.8 ± 2.7 μm and 186.9 ± 2.6 μm, respectively; P < .001). Mean foveal thickness was 200.2 ± 2.7 μm for Caucasian, 181.0 ± 3.7 μm for African-American, and 194.7 ± 3.9 μm for Hispanic subjects. Mean foveal thickness was significantly less for African-American than Caucasian (P < .0001) or Hispanic subjects (P = .005). Center point foveal thickness and mean foveal thickness showed a significant increase with age. Conclusions: There are statistically significant differences in retinal thickness between subjects of different race, gender, and age. When compared to Caucasian and Hispanic subjects, African-American race is a predictor of decreased mean foveal thickness; and male sex (regardless of race) is a significant predictor of increased mean foveal thickness. Mean foveal thickness is similar among diabetics and nondiabetics when data are controlled for age, race, and sex. These results suggest that studies comparing OCT measurements should carefully control for age-based, race-based, and gender-based variations in retinal thickness.
AB - Purpose: To detect differences in retinal thickness among patients of different race, gender, and age using Stratus OCT. Design: Cross-sectional study. Methods: In a multicenter, university-based study, 126 patients with no history of ocular disease were enrolled (78 diabetics without retinopathy and 48 nondiabetics). Optical coherence tomography measurements were performed using Stratus OCT. Statistical comparisons of center point foveal thickness and mean foveal thickness were made using generalized estimating equations adjusting for diabetic status, race, age, and gender. Results: The study population consisted of 36% male subjects, 39% Caucasian, 33% African-American, and 28% Hispanic. Mean foveal thickness was 191.6 ± 2.7 μm and 194.5 ± 2.7 μm for diabetics and nondiabetics, respectively (P = .49). Mean foveal thickness in male subjects was significantly larger than in female (201.8 ± 2.7 μm and 186.9 ± 2.6 μm, respectively; P < .001). Mean foveal thickness was 200.2 ± 2.7 μm for Caucasian, 181.0 ± 3.7 μm for African-American, and 194.7 ± 3.9 μm for Hispanic subjects. Mean foveal thickness was significantly less for African-American than Caucasian (P < .0001) or Hispanic subjects (P = .005). Center point foveal thickness and mean foveal thickness showed a significant increase with age. Conclusions: There are statistically significant differences in retinal thickness between subjects of different race, gender, and age. When compared to Caucasian and Hispanic subjects, African-American race is a predictor of decreased mean foveal thickness; and male sex (regardless of race) is a significant predictor of increased mean foveal thickness. Mean foveal thickness is similar among diabetics and nondiabetics when data are controlled for age, race, and sex. These results suggest that studies comparing OCT measurements should carefully control for age-based, race-based, and gender-based variations in retinal thickness.
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U2 - 10.1016/j.ajo.2009.09.025
DO - 10.1016/j.ajo.2009.09.025
M3 - Article
C2 - 20042179
AN - SCOPUS:76749119390
SN - 0002-9394
VL - 149
SP - 496-502.e1
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 3
ER -