TY - JOUR
T1 - Retinal sensitivity is a valuable complementary measurement to visual acuity — a microperimetry study in patients with maculopathies
AU - Liu, Hongting
AU - Bittencourt, Millena G.
AU - Wang, Jiangxia
AU - Sepah, Yasir J.
AU - Ibrahim-Ahmed, Mohamed
AU - Rentiya, Zubir
AU - Jang, Hyun Soo Kevin
AU - Moradi, Ahmadreza
AU - Nguyen, Quan Dong
N1 - Funding Information:
The Johns Hopkins University and the University of Nebraska Medical Center have received research support from Optos, Inc. Optos had no role in the design or conduct of this research. The study was supported by a Wilmer Research Grant Award (HL) and Research to Prevent Blindness (QDN). Dr. Nguyen serves on the Scientific Advisory Board for Optos, Inc.
Publisher Copyright:
© 2015, Springer-Verlag Berlin Heidelberg.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Purpose: To evaluate changes in macular sensitivity, as measured with microperimetry, among patients with maculopathy and stable visual acuity (VA). Methods: Macular sensitivity was assessed using the Spectral OCT/SLO™ microperimetry (OCT/SLO, Optos Plc., Dunfermline, UK) in 25 eyes (16 patients) with maculopathy and stable VA (<5 letters change in ETDRS score) at two consecutive clinic visits. To take the limits of the test–retest repeatability of the OCT/SLO into account, coefficient of repeatability (CoR) was employed to estimate the probability of the sensitivity changes being secondary to measurement noise. Results: The point sensitivity changes were statistically significant (Wilcoxon signed-rank test, P < 0.001). Seventy-seven points (11 %) out of a total of 700 sensitivity points had a genuine sensitivity change, with a mean increase of 8.6 ± 2.6 dB in 35 points and a mean decrease of 7.9 ± 2.2 dB in 42 points. Conclusions: Point-to-point change in macular sensitivity can be used as a biomarker of changes in disease activity in patients with maculopathy, and can be more accurate than either mean sensitivity or BCVA in detection of changes in macular function. The measurement variability should be considered when observing the local sensitivity changes.
AB - Purpose: To evaluate changes in macular sensitivity, as measured with microperimetry, among patients with maculopathy and stable visual acuity (VA). Methods: Macular sensitivity was assessed using the Spectral OCT/SLO™ microperimetry (OCT/SLO, Optos Plc., Dunfermline, UK) in 25 eyes (16 patients) with maculopathy and stable VA (<5 letters change in ETDRS score) at two consecutive clinic visits. To take the limits of the test–retest repeatability of the OCT/SLO into account, coefficient of repeatability (CoR) was employed to estimate the probability of the sensitivity changes being secondary to measurement noise. Results: The point sensitivity changes were statistically significant (Wilcoxon signed-rank test, P < 0.001). Seventy-seven points (11 %) out of a total of 700 sensitivity points had a genuine sensitivity change, with a mean increase of 8.6 ± 2.6 dB in 35 points and a mean decrease of 7.9 ± 2.2 dB in 42 points. Conclusions: Point-to-point change in macular sensitivity can be used as a biomarker of changes in disease activity in patients with maculopathy, and can be more accurate than either mean sensitivity or BCVA in detection of changes in macular function. The measurement variability should be considered when observing the local sensitivity changes.
KW - Macular sensitivity
KW - Maculopathy
KW - Visual acuity
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U2 - 10.1007/s00417-015-2974-6
DO - 10.1007/s00417-015-2974-6
M3 - Article
C2 - 25744333
AN - SCOPUS:84947619073
VL - 253
SP - 2137
EP - 2142
JO - Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie
JF - Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie
SN - 0721-832X
IS - 12
ER -