Retinal Pigment Epithelial Cells Release An Inhibitor Of Neovascularization

Bert M. Glaser, Peter A. Campochiaro, John L. Davis, Misao Sato

Research output: Contribution to journalArticlepeer-review


Human retinal pigment epithelial cells in culture were found to release a substance (or substances) that causes the regression of new blood vessels on the chick embryonic yolk sac and inhibits proliferation of fetal bovine aortic endothelial cells in vitro. Neither astrocytes nor fibroblasts, under identical test conditions, released detectable inhibitors of neovascularization or endothelial cell growth. Subconfluent and superconfluent cultures of human retinal pigment epithelial cells released higher levels of inhibitor than confluent cultures.

Original languageEnglish (US)
Pages (from-to)1870-1875
Number of pages6
JournalArchives of ophthalmology
Issue number12
StatePublished - Dec 1985

ASJC Scopus subject areas

  • Ophthalmology


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